目的：研究趋化因子CCL25，CCL25的受体CCR9在溃疡性结肠炎（UC）中的表达情况以及与UC病变程度和范围的关系及相关性，探讨其在UC发病机制中的作用。方法用免疫组织化学法检测32例活动期UC及22例正常对照石蜡包埋组织中CCL25及CCR9的表达情况。结果 UC组CCL25及CCR9均为阳性表达。对照组为阴性或弱阳性表达。CCL25及CCR9在UC组的表达与对照组比较，差异有统计学意义（P<0.01）。UC病变范围越广、程度越重，CCL25及CCR9表达阳性率越高，CCL25和CCR9表达具有相关性（r=0.759，P<0.01）。结论 CCL25/CCR9相互作用参与了UC的发生和发展。CCL25/CCR9高低反映了疾病的炎症程度，且可能作为药物治疗的潜在靶点。%ObjectiveTo investigate the role and the expression of chemokine CCL25and its receptor CCR9 in ulcerative colitis(UC)and to explore the relationship between CCL25 and CCR9 and the severity of disease. Methods The level of CCL25 and CCR9 in colon mucosa of UC patients was detected by immunohistochemistry method.Results The level of CCL25 and CCR9 in colon mucosa of UC patients were much higher than that of normal controls. The expressions of CCL25 and CCR9 were related to the extent of lesion and the degree of disease. The expression of CCL25 was significantly correlated with that of CCR9(r=0.759,P<0.01).Conclusions The expression of CCL25 is correlated with that of CCR9,CCL25 and CCR9 are closely related with the occurrence and development of UC. The expressions of CCL25 and CCR9 reflect the degree of inflammation of UC, and suggesting that CCL25 or CCR9 antagonism may represent a relevant pharmacological target for the design of novel pharmacological treatments in human UC.
展开▼
