Purpose To evaluate the clinical significance of quantitative analysis of EBV related antibody and CD44 before and after the radiotherapy in plasma of NPC patients. Methods 99 NPC patients with preliminary diagnosis in Zhejiang Tumor Hospital form 2008 September to 2009 October were rescuited, levels of EBV-VCA-IgA,EBV-EA-IgA and CD44 before and after radiotherapy were evaluated. Result The level of serum EBV-VCA-IgA before and after radiotherapy showed a significant difference(P=0.001),but the level of serum EBV-EA-IgA showed no difference(P=0.192).Respectively,serum CD44 before and after radiotherapy were(76.77±10.08), (73.23±12.55)(P=0.002),the difference was significant.Before radiotherapy,the difference of CD44 inⅡ、Ⅲ、Ⅳstage group were significant(83.12±3.00)、(78.11±10.39)、(74.35±9.96),P=0.035). Conclusion Compared with EBV-EA-IgA,EBV-VCA-IgA was more sensitive and effective in curative effect monitoring.The high expression of CD44 may be related to the stage of NPC,the early stage of nasopharyngeal carcinoma has more power in metastasis potential.%目的：比较鼻咽癌（NPC）患者治疗前后血清EBV抗原抗体及CD44变化水平，为临床疗效判断及预测预后提供理论依据及客观指标。方法2008年9月至2009年10月初治鼻咽癌Ⅱ-Ⅳ期患者99例，治疗前检测外周血EB病毒衣壳抗原抗体（EBV-VCA-IgA）、早期抗原抗体（EBV-EA-IgA）及CD44水平，放疗结束时再次检测上述指标。结果99例鼻咽癌患者治疗前、后血清中EBV-VCA-IgA表达水平差异有统计学意义（P=0.005），EBV-EA-IgA差异无统计学意义（P=0.162）。治疗前、后血清中CD44分别为（76.77±10.08）、（73.23±12.55），P=0.002，差异有统计学意义。Ⅱ、Ⅲ、Ⅳ期患者治疗前血清CD44分别为（83.12±3.00）、（78.11±10.39）、（74.35±9.96），P=0.035，差异有统计学意义。结论与EBV-EA-IgA相比，EBV-VCA-IgA用于鼻咽癌疗效判断及监测病情可能更为灵敏和准确。CD44的高表达可能与鼻咽癌分期相关，早期鼻咽癌具有较强的转移潜力。
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