Objective To explore the incidence of coronary calcification in patients with chronic kidney disease (CKD),and its prognosis evaluation value at a single center. Methods The blood calcium(Ca)and phosphate(P)in 136 CKD patients and 50 healthy persons were detected,and the coronary calcification score were measured by multi-slice spiral computed tomography(MSCT). Result Compared with health controls,incidence of coronary calcification and severer coronary calcification,level of P and Ca-P product were significantly higher in CKD patients of different stages,and with the severity aggravating of CKD,incidence of coronary calcification and severer coronary calcification,level of Ca-P product were increased(P<0.05). The incidence of coronary calcification and severer coronary calcification increased with the dialysis duration(P<0.05). During 1 year follow-up,the incidence of MACE in calcification group was 16.9%,significantly higher than that of non-calcification group 5.6%(P<0.05). Conclusions From our single center’s experience,patients with CKD has higher incidence of coronary calcification,especially for the long-term support dialysis patients,and the degree of coronary calcification is correlated with the prognosis of CKD.% 目的探讨慢性肾脏病(CKD)冠状动脉钙化发生率及其在预后评估中的应用.方法测定136例CKD患者及50例同期健康体检者血钙(Ca)、血磷(P)水平，并采用多层螺旋CT(MSCT)检测所有观察对象冠状动脉钙化积分情况.比较不同组间患者的冠状动脉钙化及主要心脏不良事件(MACE)发生情况.结果与对照组比较，三组不同CKD分期患者的冠状动脉钙化率、重度钙化率、血磷及钙磷乘积均明显升高(P<0.05)；且随着CKD病情程度的增加，患者冠状动脉钙化率、重度钙化率、钙磷乘积均依次增加(P<0.05)；随着透析治疗时间的延长，冠状动脉钙化率、重度钙化率均呈上升趋势(P<0.05)；随访1年，钙化组MACE发生率为16.9%，显著高于非钙化组为5.6%(P<0.05).结论 CKD患者冠状动脉钙化发生率较高，尤其是长期维持性透析患者，且冠状动脉钙化程度与CKD患者的预后有关.
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