目的探讨食管腺癌前期(BE)患者食管病理分型、组织异型性与环氧合酶2(COX-2)及幽门螺杆菌(HP)感染的关系.方法采用免疫组化法及14C-尿素呼气试验检测137例BE患者及134例健康者食管中COX-2和HP感染的表达情况.结果 COX-2在BE中高表达,而在正常组织中无表达或弱表达,COX-2表达与BE病理类型及组织异型性,差异有统计学意义(P<0.01)；HP感染率在BE及正常组织中表达差异无统计学意义(P>0.05),与BE病理类型及组织异型性差异无统计学意义(P>0.05).结论 BE中COX-2的表达与BE的病理类型及组织异型性有关,提示COX-2表达与BE的发生发展有密切关系,而BE的发生与HP状态无关.%Objective To explore the correlations of pathological typing, tissue atypia and COX-2 and helicobacter pylori (HP) infection in the patients of Barrett esophagus(BE). Methods Immunohistochemisty and 14C-urea breath test were applied to measure the expression of COX-2 and HP infection in 137 patients of BE and 134 healthy people as control. Results The expression of COX-2 was high in BE while low or none in normal tissues, the expression of COX-2 was statistically different among different pathological types, tissue atypia of BE(P<0.01), the difference of HP infection rates was not statistically different among different pathological types, tissue atypia of BE(P>0.05). Conclusions The expression of COX-2 is statistically correlated to different pathological types, tissue atypia of BE,which implied that the COX-2 has a close relationship to the progression of BE while HP doesn’t.
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