目的探讨支原体感染的不孕症患者的AsAb和AEMAb与生殖道局部炎性因子的水平及相关性。方法选择自2010年1月至2013年1月不孕症患者361例，检查有无UU感染后于次日晨检测血清抗精子抗体（AsAb）、抗子宫内膜抗体（AEMAb），并检验宫颈管IL-6、TNF-α、IFN-γ。结果361例患者中共检出UU阳性患者127例，UU阴性患者234例。UU阳性组AsAb、AEMAb检出率与UU阴性组检出率比较差异有统计学意义（P<0.05）。UU阳性组TNF-α较UU阴性组有显著性升高（P<0.05），IFN-γ、IL-6较UU阴性组有极显著性差异（P<0.01）。AsAb与TNF-α、IFN-γ呈显著正相关（P<0.01，P<0.05），与IL-6未见显著相关性（P>0.05）。AEMAb与TNF-α、IFN-γ、IL-6呈显著正相关（P<0.05）。结论 UU感染不孕症患者AsAb和AEMAb的产生与生殖道炎性因子的水平密切相关。%Objective To investigate AsAb and AEMAb and reproductive tract inflammatory factor levels and correlation in mycoplasma infection in patients with infertility. Methods 361 cases of infertility patients from January 2010 to January 2013 in department of Obstetrics and Gynecology were checked for UU infection and in the next morning the serum anti sperm antibodies (AsAb),endometrial antibody (AEMAb) and inspection of the cervix tube IL-6,TNF-alpha,IFN-gamma were detected. Results 127 cases of the UU-positive patients,234 cases of UU-negative patients were detected. AsAb, AEMAb in UU positive group detection rate than the UU the negative group detection rate had statistically significant differences (P <0.05). TNF-alpha UU positive group than UU negative group was significantly higher (P<0.05),IFN-gamma,IL-6 than UU negative group there was a significant difference (P<0.01). AsAb with TNF-α,IFN-γ had a significant positive correlation (P<0.01,P<0.05),and IL-6 did not show a significant correlation (P>0.05). AEMAb with TNF-α,IFN-γ, IL-6 had a significant positive correlation (P<0.05). Conclusion Infertility patients with UU infection had elevated AsAb and AEMAb level and the level of the genital tract inflammatory factors,which are closely related.
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