Objective To investigate the correlation between renal involvement and serum TNF-α,IL-6,IL-2 and vWF,ET-1 levels in plasma in children with Henoch-Schonlein purpura. Methods 64 children affected by HSP were enrolled into the study,including 33 cases of Henoch-Schonlein purpura nephritis and 31 patients without renal involvement. while 20 cases of healthy children selected as controls. serum TNF-α,IL-6,IL-2 levels were Measured by ELISA,and plasma ET-1, vWF levels Measured by radioimmunoassay. Results serum TNF-α,IL-6,IL-2 and plasma vWF levels in two group were significantly higher than the control,the difference was statistically significant(P<0.01),and significantly decreased in remission(P<0.001). Serum TNF-αin Henoch-Schonlein purpura nephritis group increased significantly,although decreased significantly in remission,but still higher than the normal control and the group of patients without renal involvement,the difference was statistically significant(F=4.973,P<0.05).Serum TNF-α,IL-6,IL-2,and plasma vWF levels in the group of patients without renal involvement after treatment for two weeks compared with control have no difference(P>0.05). plasma ET-1 levels at the outset and after treatment for two weeks in the two group were no significant difference with control in .(P>0.05).a significant positive correlation Result ed to be among the following parameters: renal score and vWF (rho=0.73,P<0.01),renal score and TNF-α(rho=0.92 P<0.01). Conclusion Serum TNF-α,IL-6,IL-2 and plasma vWF involved in the pathogenesis of Henoch-Schonlein purpura. TNF-α,vWF are expected as the marker of renal involvement in children with Henoch-Schonlein purpura.%目的：探讨血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-2（IL-2）及血浆血管性假血友病因子（vWF）、内皮素（ET-1）与过敏性紫癜患儿肾损伤的相关性。方法64例过敏性紫癜患儿（紫癜性肾炎33例，无肾炎31例），采用ELISA法及放射免疫法分别检测急性期和缓解期的血清TNF-α、IL-6、IL-2及血浆vWF、ET-1水平，并与正常儿童对照。结果两组过敏性紫癜患儿急性期血清TNF-α、IL-6、IL-2及血浆vWF水平均明显高于对照组，缓解期均明显下降。紫癜性肾炎组患儿急性期血清TNF-α水平明显升高，缓解期虽有明显下降，但仍高于对照组（F=4.973，P<0.05），血清IL-6、IL-2及血浆vWF缓解期与对照组差异均无统计学意义。无肾炎组患儿缓解期血清TNF-α、IL-6、IL-2及血浆vWF水平与对照组比较差异均无统计学意义。两组过敏性紫癜患儿的血浆ET-1水平在急性期、缓解期与对照组比较差异无统计学意义。肾功能评分与vWF、TNF-α呈正相关（rho=0.73，rho=0.92，P均<0.01）。结论血清TNF-α、IL-6、IL-2及血浆vWF参与过敏性紫癜的发病过程，TNF-α、vWF有望作为检测过敏性紫癜患儿肾损伤程度的指标。
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