目的 探讨血尿酸与2型糖尿病(T2DM)患者心血管并发症的关系,为预防和治疗糖尿病并发症提供理论依据.方法 将268例T2DM患者分为T2DM心血管并发症组和T2DM非心血管并发症组,并选择体检的健康人做对照,比较各组血尿酸、胆固醇、甘油三酯、高密度脂蛋白、空腹血糖、体重指数、病程和血压的差异,并对心血管并发症组和非心血管并发症组差异有统计学意义的指标进行Logistic回归分析,探讨糖尿病心血管并发症的危险因素.结果 T2DM心血管并发症组、T2DM非心血管并发症组体重指数、收缩压、舒张压、空腹血糖、甘油三酯和血尿酸均显著高于正常对照组,差异有统计学意义(P<0.05);T2DM心血管并发症组较非心血管并发症组血尿酸高、收缩压高、病程长,差异有统计学意义(P<0.05);多元回归分析显示,病程、收缩压和血尿酸与T2DM心血管并发症呈正相关.结论 与病程和高血压一样,血尿酸是T2DM心血管并发症的独立危险因素.%Objective To know the relationship between blood uric acid and cardiovascular complications of the patients of type 2 diabetes mellitus(T2DM). Method 144 patients who have got cardiovascular complications named as Observed group, 124 patients who have not got cardiovascular complications named as compared group. All the patients came from The 1 th People Hospital of Taizhou, and were diagnosed T2DM according to WHO. We detected the following parameters: cholesterol, glycerin trilaurate,high density lipoprotein, blood uric acid, fasting blood - glucose, body mass index, course of disease and blood pressure. The difference of these parameters of the both groups were compared. Result There was significant difference between the T2DM patients and healthy persons of glycerin trilaurate, blood uric acid, fasting blood -glucose, body mass index, and blood pressure.The blood uric acid, systolic pressure and course of disease have significant difference between observed group and compared group,and they positively correlate with cardiovascular complications of T2DM patients. Conclusion The blood uric acid, systolic pressure and course of disease are independent risk factors of patients of T2DM.
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