Objective To examine the levels of serum resistin in dialysis patients with end stage renal disease ( ESRD) , and investigate the relationship between serum resistin and high sensitivity C - reactive protein ( hs - CRP) , tumor necrosis factor - a (TNF - a) , albumin,blood lipid. Methods 144 dialysis patients with end stage renal failure and 40normal healthy persons were involved in this study. The patients were divided into two groups: patients with hemodialysis ( HD, 96 cases) and patients with peritonealdialysis(PD,48cases). The levels of serum resistin, hs -CRP, TNF - a. were detected by means of ELISA. The levels of serum albumin, cholesterol(TC) , triglyceride(TG) were detected by conventional methods. Results The levels of serum resistin were significantly higher in dialysis patients [ HD (15. 20 ±3. 22)ng/ml, PD (11. 12 ±2. 02)ng/ml] than those in healthy subjects [ (5. 53 ± 1. 86 ) mg/L] , ( P < 0. 01 ). The levels of serum resistin were significantly higher in PD patients than those in HD patients. Correlation analysis indicates; Serum resistin levels in HD patients were positively related to serum hs - CRP( r =0. 359 , P <0. 01)) ,TNF-ct(r=0. 487,P<0.05) ,and TG(r =0. 015 ,P <0. 05) , and negatively related to serum Alb( -0. 255 ,P <0. 05 ). Serum resistin levels in PD patients were positively related to serum hs - CRP( r = 0. 224, P < 0. 05 ) , TNF - a ( r = 0. 220, P < 0.01 ), TC(r=0. 055,P<0. 05 ), TG(r =0. 042, P <0. 05) , and negatively related to serum Alb(r= - 0. 201, P < 0. 05 ). Conclusions The levels of serum resietin is markedly increased in dialysis patients with ESRD. In addition, the study demonstrates the relationship betreen serum resistin and TNF - a., hs - CRP, Alb, TC, TG levels and suggestes that resistin might play a role in the sub - clinical inflammation associatet with ESRD.%目的 研究终末期肾脏病(ESRD)透析患者血清抵抗素(Resistin)水平及其与超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、血清白蛋白(Alb)、血脂等的关系.方法 选择ESRD透析患者144例,分为血液透析组(96例)和腹膜透析组(48例),另设正常对照组(40例).用ELISA方法检测血清Resistin、hs-CRP和TNF-α,同时常规测定血清白蛋白(Alb)、血总胆固醇(TC)和甘油三酯(TG),分析Resistin与这些血清因子的相关性.结果 (1)透析患者血清Resistin水平:血液透析组(15.20±3.22)ng/ml,腹膜透析组(11.12±2.02)ng/ml,对照组(5.53±1.86)mg/L,差异均有统计学意义(P<0.01).(2)相关性分析:血液透析患者Resistin与hs-CRP(r=0.359,P<0.01)、TNF-α(r=0.487,P<0.05)、TG(r=0.015,P<0.05)成正相关,与Alb(r=-0.255,P<0.05)成负相关;腹膜透析患者Resistin与hs-CRP(r=0.224,P<0.05)、TNF-α((r=0.220,P<0.01)、TC(r=0.055,P<0.05)、TG(r=0.042,P<0.05)成正相关,与TC(r=-0.201,P<0.05)成负相关.结论 在终末期肾脏病,无论血液透析、腹膜透析患者,其Resistin均明显升高,并与hs-CRP、TNF-α、Alb、TC、TG检测结果有关,提示Resistin可能对ESRD透析患者的微炎症起一定作用.
展开▼
