Objective To compare efficacy and safety of clonazepam with diazepam in treating epilepsy.Methods 56 epilepsy patients were randomly assigned to clonazepam or diazepam treatment.The frequency of epilepsy decreased 50-75％ and 75％ above had regarded as "effective" and "effective significantly" standard respectively.Results "effective" rates of clonazepam and diazepam had significant difference (92.9％ vs.71.4％ ),while the difference of their "effective significantly" rate was not significant (78.6％ vs.60.7％ ).Side effects of these two drugs were similar.Conclusion Clonazepam was effective and safe in treating epilepsy.%目的比较氯硝西泮和地西泮针剂治疗癫痫状态的疗效和安全性。方法符合癫痫状态诊断标准的56例住院患者，随机分为两组进行对照研究。分别给与氯硝西泮1～14mg/d和地西泮5～100mg/d，以发作频率减少50～75％和75％以上作为治疗有效和显效的评定标准，以TESS和实验室检查评价药物副反应。结果氯硝西泮治疗有效率为92.9％，地西泮为71.4％，两者有显著性差异；显效率氯硝西泮为78.6％，地西泮为60.7％，两者无显著差异。即刻止痫作用两者相仿。平均药效持续时间氯硝西泮显著长于地西泮。药物副反应两者相似。结论氯硝西泮治疗癫痫状态有效、安全，起效迅速，药效持续时间长。
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