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首页> 中文期刊> 《浙江临床医学》 >乙肝与丙肝病毒感染患者肝脏病理特点比较

乙肝与丙肝病毒感染患者肝脏病理特点比较

         
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目的 比较乙型肝炎与丙型肝炎感染者肝脏病理特点.方法 选取2014年4月至2017年4月接受肝组织活检的慢性乙型肝炎患者134例为乙肝组,同期慢性丙型肝炎患者54例为丙肝组.采用雅培i2000?全自动化学发光免疫分析仪检测患者丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST);采用快速经皮穿刺活检术进行肝组织活检,由2名有经验的病理医师对所有标本进行审核诊断,确定患者肝组织炎症活动程度分级及肝组织纤维化分期.结果 丙肝组炎症分级≥G2的患者49例,乙肝组炎症分级≥G2的患者103例,两组比较差异有统计学意义(P0.05).结论 慢性丙型肝炎感染者肝组织炎症和纤维化水平高于慢性乙型肝炎感染者,具有一定的形态学鉴别诊断意义.%Objective To?explore?the?differences?between?chronic?hepatitis?c?infection?and?chronic?hepatitis?b?infection?in?liver?pathology.?Method? A?total?of?134?patients?with?chronic?hepatitis?b?who?received?liver?biopsy?in?our?hospital?from?April?2014?to?April?2017?were?selected?as?hepatitis?b?group,and?54?patients?with?chronic?hepatitis?c?were?recorded?as?hepatitis?c?group.The?levels?of?Alanine?aminotransferase?and?Aspartate?aminotransferase?were?detected?by?the?Accpei?I2000?automatic?chemiluminescence?immunoassay.Liver?biopsy?was?performed?with?rapid?percutaneous?needle?biopsy.All?specimens?were?examined?and?diagnosed?by?two?experienced?pathologists?to?determine?the?degree?of?inflammatory?activity?in?the?liver?tissue?and?the?staging?of?hepatic?fibrosis.?Results In?the?hepatitis?c?group,there?were?49?cases(90.74%)of?patients?with?inflammatory?grade?≥G2.In?the?hepatitis?b?group, there?were?103?cases(76.87%)of?patients?with?inflammatory?grade?≥G2.The?difference?was?statistically?significant(P0.05).?Conclusion The?liver?tissue?inflammation?and?fibrosis?level?of?patients?with?chronic?hepatitis?c?are?higher?than?those?infected?with?chronic?hepatitis?b,and?it?has?morphological?differential?diagnosis?significance.

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