目的 探讨乳腺癌组织中锌指蛋白217(ZNF217)和p53蛋白的表达特点及其临床意义.方法 采用免疫组化EnVision法检测80例乳腺癌(乳腺癌组)和对应癌旁组织(对照组)中ZNF217和p53蛋白的表达情况,分析上述指标与临床病理因素(年龄、肿瘤大小、分型、组织学分级、临床分期及淋巴结转移)的关系,以及乳腺癌组织中ZNF217与p53表达的相关性.结果 乳腺癌组织中ZNF217和p53蛋白阳性表达率分别为71.25％(57/80)和73.75％(59/80),高于对应癌旁组织的20.00％(16/80)和10.00％(8/80),差异均有统计学意义(均P＜0.01);ZNF217和p53蛋白表达均与乳腺癌临床分期及淋巴结转移有关(均P＜0.01),而均与患者年龄、肿瘤大小、组织学类型及分级无关(均P ＞0.05);乳腺癌组织中ZNF217与p53的表达呈正相关(P＜0.05).结论 乳腺癌组织中ZNF217和p53蛋白表达明显升高,其异常表达与乳腺癌的发生、发展及转移有关.%Objective To investigate the expression of zinc finger protein ZNF217 and p53 in breast cancer and its significance.Methods The expression of ZNF217 and p53 protein in 80 cases of breast cancer (breast cancer group) and corresponding adjacent tissues (control group) were detected by immunohistochemical En Vision method.The associations between expression of those proteins and clinicopathological factors (age,tumor size,typing,histological grade,clinical stage and lymph node metastasis) was analyzed,the correlation between the expression of ZNF217 and p53 in breast cancer tissues was also analyzed.Results The positive rates of ZNF217 and p53 expression were significantly higher than those in non-cancerous adjacent breast tissues (P＜0.05).The expression of ZNF217 and p53 protein was correlated with clinical stage and lymph node metastasis,but not correlated with age,tumor size,histological type and grading (P ＞0.05).There was a positive correlation between ZNF217 and p53 expression in breast cancer (P ＞0.05).Conclusion The expression of ZNF217 and p53 is significantly increased in breast cancer,which is closely correlated with occurrence,development and metastasis of breast cancer.
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