Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway

机译：CalO1的结构特征：加利车霉素生物合成途径中假定的奥数酸甲基转移酶

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摘要

The X-ray structure determination at 2.4 Å resolution of the putative orsellinic acid C3 O-methyltransferase (CalO1) involved in calicheamicin biosynthesis is reported. Comparison of CalO1 with a homology model of the functionally related calicheamicin orsellinic acid C2 O-methyltransferase (CalO6) implicates several residues that are likely to contribute to the regiospecificity of alkylation. Consistent with the proposed requirement of an acyl-carrier-protein-bound substrate, this structural study also reveals structural determinants within CalO1 that are anticipated to accommodate an association with an acyl carrier protein.

机译：报道了涉及加利车霉素生物合成的原奥数酸C3 O-甲基转移酶（CalO1）的X射线结构测定为2.4Å。将CalO1与功能相关的加利车霉素奥山梨酸C2 O-甲基转移酶（CalO6）的同源性模型进行比较，可能会涉及多个可能有助于烷基化区域特异性的残基。与提出的对酰基载体蛋白结合的底物的要求相一致，该结构研究还揭示了CalO1中的结构决定簇，这些决定簇有望与酰基载体蛋白结合。

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期刊名称 Acta Crystallographica Section D: Biological Crystallography
作者
Aram Chang; Shanteri Singh; Craig A. Bingman; Jon S. Thorson; George N. Phillips Jr;
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作者单位

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年(卷),期 -1(67),Pt 3
年度 -1
页码 197–203
总页数 7
原文格式 PDF
正文语种
中图分类分子生物学;生化遗传学;生化药理学;生物物理学;
关键词
enediynes S-adenosylmethionine polyketides biosynthesis natural products acyl carrier proteins;

机译：烯二炔;S-腺苷甲硫氨酸;聚酮化合物;生物合成;天然产物;酰基载体蛋白;

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专利

1. Structural characterization of CalO2: a putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway. [J] . McCoy JG, Johnson HD, Singh S, Proteins: Structure, Function, and Genetics . 2009,第1期

机译：CalO2的结构表征：加利车霉素生物合成途径中假定的奥数酸P450氧化酶。
2. Cloning, characterization, and expression profile of an insect farnesoic acid O-methyltransferase orthologue from the mud crab Scylla paramamosain Estampador, 1950 (Brachyura: Portunidae): putative relationship with methyl farnesoate [J] . Zhao Ming, Zhang Fengying, Jiang Keji, Journal of Crustacean Biology . 2018,第4期

机译：来自泥蟹Scylla Paramamosain Estampador的杀虫法游隼酸O-甲基转移酶直酯，1950（Brachyura：Portunidae）的克隆，表征和表达谱系：与法里甲酸甲基甲基甲基
3. Cloning and characterization of a putative farnesoic acid O -methyltransferase gene from the brown planthopper, Nilaparvata lugens [J] . Baojun Yang, Chengwei Zhang, Jianhua Gu, Journal of Insect Science . 2010,第1期

机译：棕色Planthopper，Nilaparvata Lugens的推定法呢酸O-甲基转移酶基因的克隆与表征
4. Identification of a Putative Ganoderic Acid Pathway Enzyme in a Ganoderma Australe Transcriptome by Means of a Hidden Markov Model [C] . Germán López-Gartner, Daniel Agudelo-Valencia, Sergio Casta?o, International Conference on Practical Applications of Computational Biology and Bioinformatics . 2015

机译：通过隐马尔可夫模型鉴定Ganoderma Authareale转录组中推定的红花酸途径酶
5. Characterization of T24D1.4(ok809) a putative alpha-1,2 glucosyltransferase in C. elegans and detailed structural analysis of the lipid linked oligosaccharide pathway via MSN [D] . Wiswall, William Cobb, Jr. 2009

机译：秀丽隐杆线虫中T24D1.4（ok809）假定的α-1,2葡萄糖基转移酶的表征和通过MSN的脂质连接寡糖途径的详细结构分析
6. Structural characterization of CalO2: a putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway [O] . Jason G. McCoy, Heather D. Johnson, Shanteri Singh, -1

机译：CalO2的结构表征：加利车霉素生物合成途径中假定的奥数酸P450氧化酶
7. Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway [O] . Chang, Aram, Singh, Shanteri, Bingman, Craig A., 2011

机译：CalO1的结构特征：加利车霉素生物合成途径中假定的奥数酸甲基转移酶

Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway

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