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首页> 美国卫生研究院文献>Advanced Pharmaceutical Bulletin >Nanotechnology in Wound Healing; Semisolid Dosage Forms Containing Curcumin-Ampicillin Solid Lipid Nanoparticles, in-Vitro, Ex-Vivo and in-Vivo Characteristics
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Nanotechnology in Wound Healing; Semisolid Dosage Forms Containing Curcumin-Ampicillin Solid Lipid Nanoparticles, in-Vitro, Ex-Vivo and in-Vivo Characteristics

机译：伤口愈合中的纳米技术；含有姜黄素-氨苄青霉素固体脂质纳米颗粒的半固体剂型，具有体外，体外和体内特性

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Purpose: Wound healing is a natural biologic process, but the duration of it may take too long. Trying to shorten this process is one of the challenges for scientists. Many technologies were applied to achieve this goal as well as nanotechnology. In this study semi solid formulations containing curcumin and ampicillin solid lipid nanoparticles (SLNs) were prepared to evaluate as burn wound healing agent.Methods: Curcumin as an anti-inflammatory and anti-bacterial agent and ampicillin as an antibiotic were applied. In-vitro and in-vivo evaluations were carried out. Particle size, loading efficiency, release profile, morphology and anti-bacterial efficacy of desired nanoparticles were evaluated at first. Then the remaining of the antibacterial effect in semi solid preparations was studied. Animal studies for both toxicology using rabbits and skin burn model using rats were designed. Pathology studies after applying of formulations was done too.Results: Desired nanoparticles were spherical in shape and particle size in range of 112-121 nm, with low zeta potential. For increasing stability of particles they were freeze dried using cryoprotectant. Lyophilized particles show no significant size enlargement. Results showed that both ointment and gel preparations have reasonable anti-bacterial effects, both of them cause increasing in the rate of wound healing in comparison with placebos and control groups and none of the formulations showed acute toxicity.Conclusion: It seems that using nanotechnology could shorten wound healing process to reduce treatment costs and increase compliance of patients.
机译：目的：伤口愈合是自然的生物过程，但是持续时间可能太长。试图缩短这一过程是科学家的挑战之一。纳米技术和许多技术都被用来实现这一目标。在这项研究中，制备了包含姜黄素和氨苄西林固体脂质纳米颗粒（SLNs）的半固体制剂，以评估烧伤创面愈合剂的作用。方法：姜黄素作为抗炎和抗菌剂，氨苄西林应用抗生素。进行了体内和体外评估。首先评估所需纳米颗粒的粒径，负载效率，释放曲线，形态和抗菌功效。然后研究了半固体制剂中剩余的抗菌作用。设计了使用兔子进行毒理学和使用大鼠进行皮肤烧伤模型的动物研究。 结果：所需的纳米颗粒呈球形，粒径在112-121 nm之间，ζ电位低。为了增加颗粒的稳定性，使用冷冻保护剂将它们冷冻干燥。冻干的颗粒没有显示出明显的尺寸增大。结果表明，软膏和凝胶制剂均具有合理的抗菌作用，与安慰剂和对照组相比，它们均能提高伤口愈合的速度，且均未显示出急性毒性。结论：使用纳米技术似乎可以缩短伤口愈合过程，从而降低治疗成本并提高患者的依从性。

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