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首页> 美国卫生研究院文献>Advances in Pharmacological Sciences >Crude Polysaccharides from Okra Pods (Abelmoschus esculentus) Grown in Indonesia Enhance the Immune Response due to Bacterial Infection
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Crude Polysaccharides from Okra Pods (Abelmoschus esculentus) Grown in Indonesia Enhance the Immune Response due to Bacterial Infection

机译：在印度尼西亚种植的秋葵荚果（Abelmoschus esculentus）的粗多糖增强了细菌感染引起的免疫反应

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Okra pods were widely consumed by Indonesians to maintain health. The aim of this study was at investigating the potential of crude polysaccharides from okra pods on immune response in mice infected with Staphylococcus aureus. Thirty male Balb/C mice were divided into six groups: normal control, negative control, and treatment groups (administration of crude polysaccharides at doses of 25, 50, 75, and 100 mg/kg). Crude polysaccharides were administrated for fourteen days. Furthermore, mice were exposed to S. aureus at the fifteenth day. Two weeks after the end of treatment, the parameters were measured. This study showed that crude polysaccharides at a dose of 75 and 100 mg/kg improved phagocytic activity, spleen index, and splenocytes proliferation. Rising of TNF-α levels was shown in groups treated with crude polysaccharides at doses of 25, 50, and 100 mg/kg. All treatment groups showed a decreasing level of IL-17. Crude okra polysaccharides also showed a slight increase in NK cells activity and IFN-γ level. Thus, crude okra polysaccharides could act as an effective material to enhance immune response including phagocytic activity, spleen index, splenocytes proliferation, and control immune responses through cytokine production.
机译：黄秋葵荚果被印尼人广泛食用以保持健康。这项研究的目的是调查黄秋葵荚果的粗多糖对金黄色葡萄球菌感染的小鼠的免疫反应的潜力。将三十只雄性Balb / C小鼠分为六组：正常对照组，阴性对照组和治疗组（以25、50、75和100μmg/ kg的剂量施用粗多糖）。粗制多糖施用十四天。此外，在第十五天将小鼠暴露于金黄色葡萄球菌。治疗结束后两周，测量参数。这项研究表明，粗多糖的剂量为75和100μmg/ kg可以改善吞噬活性，脾指数和脾细胞增殖。用粗多糖以25、50和100μmg/ kg的剂量处理的组中TNF-α水平升高。所有治疗组均显示IL-17水平降低。秋葵粗多糖也显示出NK细胞活性和IFN-γ水平的轻微增加。因此，秋葵粗多糖可以作为增强免疫反应的有效物质，包括吞噬活性，脾指数，脾细胞增殖，并通过细胞因子的产生来控制免疫反应。

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