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Frontiers proposal. National Institute on Aging bench to bedside: estrogen as a case study

机译：边疆提案。国立老龄化研究所从床边到床旁：以雌激素为例

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On 28–29 September 2004, the National Institute on Aging (NIA) convened scientists for a workshop on the aging female brain focused on translating into clinical practice discoveries concerning estrogens and progestogens. Workshop objectives were to examine effects of estrogen and progestogen on brain and cognitive function in relation to aging, to examine consistencies and apparent discrepancies between Women’s Health Initiative Memory Study findings and other research on cognitive function, to determine whether additional hormone interventions could be developed in this area, and to offer advice on design of clinical trials for other interventions that might ameliorate cognitive aging. Following the workshop, participants joined by other interested scientists organized into regional work groups to continue the dialogue begun in Bethesda and to propose recommendations for NIA. The resulting recommendations, referred to as the “Frontiers Proposal for Estrogen and Cognitive Aging”, acknowledge the persistence of critical gaps in our understanding of how decline in ovarian steroid secretion during reproductive aging and use of ovarian steroid hormone therapy affect normal brain function and risk for late-life neurodegenerative disorders such as Alzheimer’s disease. There is a pressing need for preclinical, human, and integrated studies on the relationship between the menopausal transition and midlife exposures to estrogens, progestogens and related compounds, and risks for age-associated cognitive disorders. Research is also needed on better predictors of adverse cognitive outcomes, valid biomarkers for risks associated with hormone therapy use, enhanced tools for monitoring brain function and disease progression, and novel forms of therapy for improving long-term cognitive outcomes.
机译：2004年9月28日至29日，美国国家老龄研究所（NIA）召集了科学家参加关于女性大脑老化的研讨会，该研讨会的重点是将有关雌激素和孕激素的临床发现转化为临床实践。研讨会的目的是检查与衰老相关的雌激素和孕激素对大脑和认知功能的影响，检查妇女健康倡议记忆研究结果与其他认知功能研究之间的一致性和明显差异，以确定是否可以在体内进行其他激素干预这个领域，并为其他可能改善认知老化的干预措施的临床试验设计提供建议。研讨会之后，与会的其他有兴趣的科学家参加了会议，与会者组成了区域工作组，以继续在贝塞斯达（Bethesda）开始的对话并为NIA提出建议。由此产生的建议被称为“雌激素和认知老化前沿提案”，承认在我们理解生殖衰老过程中卵巢类固醇分泌下降以及卵巢类固醇激素疗法的使用如何影响正常脑功能和风险方面的认识存在着重大差距用于晚期神经退行性疾病，例如阿尔茨海默氏病。迫切需要进行临床前，人类和综合研究，以研究更年期过渡与中年接触雌激素，孕激素和相关化合物之间的关系以及与年龄相关的认知障碍的风险。还需要研究不良认知结果的更好预测指标，与激素治疗有关的风险的有效生物标志物，监测脑功能和疾病进展的增强工具以及改善长期认知结果的新型疗法。

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