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The preterm prediction study: the value of new vs standard risk factors in predicting early and all spontaneous preterm births. NICHD MFMU Network.

机译:早产预测研究:新的和标准的危险因素在预测早产和所有自发性早产中的价值。 NICHD MFMU网络。

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摘要

OBJECTIVES: This study was undertaken to determine the relationship between fetal fibronectin, short cervix, bacterial vaginosis, other traditional risk factors, and spontaneous preterm birth. METHODS: From 1992 through 1994, 2929 women were screened at the gestational age 22 to 24 weeks. RESULTS: The odds ratios for spontaneous preterm birth were highest for fetal fibronectin, followed by a short cervix and history of preterm birth. These factors, as well as bacterial vaginosis, were more strongly associated with early than with late spontaneous preterm birth. Bacterial vaginosis was more common--and a stronger predictor of spontaneous preterm birth--in Black women, while body mass index less than 19.8 was a stronger predictor in non-Black women. This analysis suggests a pathway leading from Black race through bacterial vaginosis and fetal fibronectin to spontaneous preterm birth. Prior preterm birth is associated with spontaneous preterm birth through a short cervix. CONCLUSIONS: Fetal fibronectin and a short cervix are stronger predictors of spontaneous preterm birth than traditional risk factors. Bacterial vaginosis was found more often in Black than in non-Black women and accounted for 40% of the attributable risk for spontaneous preterm birth at less than 32 weeks.
机译:目的:本研究旨在确定胎儿纤连蛋白,子宫颈短,细菌性阴道病,其他传统危险因素与自然早产之间的关系。方法:从1992年到1994年,在22至24周的孕周对2929名妇女进行了筛查。结果:胎儿纤连蛋白的自然早产几率最高,其次是子宫颈短和早产史。这些因素以及细菌性阴道病与早期自发性早产的关联性强。细菌性阴道病在黑人女性中更常见,并且是自发性早产的更强预测因子,而体重指数小于19.8在非黑人女性中则更强。该分析表明从黑人种族通过细菌性阴道病和胎儿纤连蛋白到自发早产的途径。早产与子宫颈短促自发性早产有关。结论:与传统的危险因素相比,胎儿纤连蛋白和子宫颈短是自发性早产的更强预测因子。黑人患细菌性阴道病的比率高于非黑人妇女,并且在不到32周的时间里,细菌性阴道病占自发早产的风险的40%。

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