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首页> 美国卫生研究院文献>Arthritis Research >Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low-density lipoprotein and exhibit decreased activity of the lipoprotein-associated phospholipase A2
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Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low-density lipoprotein and exhibit decreased activity of the lipoprotein-associated phospholipase A2

机译：患有类风湿关节炎的早期患者表现出针对轻度氧化的低密度脂蛋白的自身抗体滴度升高并且脂蛋白相关磷脂酶A2的活性降低

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Rheumatoid arthritis is a chronic inflammatory disease, associated with an excess of cardiovascular morbidity and mortality due to accelerated atherosclerosis. Oxidized low-density lipoprotein (oxLDL), the antibodies against oxLDL and the lipoprotein-associated phospholipase A2 (Lp-PLA2) may play important roles in inflammation and atherosclerosis. We investigated the plasma levels of oxLDL and Lp-PLA2 activity as well as the autoantibody titers against mildly oxLDL in patients with early rheumatoid arthritis (ERA). The long-term effects of immunointervention on these parameters in patients with active disease were also determined. Fifty-eight ERA patients who met the American College of Rheumatology criteria were included in the study. Patients were treated with methotrexate and prednisone. Sixty-three apparently healthy volunteers also participated in the study and served as controls. Three different types of mildly oxLDL were prepared at the end of the lag, propagation and decomposition phases of oxidation. The serum autoantibody titers of the IgG type against all types of oxLDL were determined by an ELISA method. The plasma levels of oxLDL and the Lp-PLA2 activity were determined by an ELISA method and by the trichloroacetic acid precipitation procedure, respectively. At baseline, ERA patients exhibited elevated autoantibody titers against all types of mildly oxLDL as well as low activity of the total plasma Lp-PLA2 and the Lp-PLA2 associated with the high-density lipoprotein, compared with controls. Multivariate regression analysis showed that the elevated autoantibody titers towards oxLDL at the end of the decomposition phase of oxidation and the low plasma Lp-PLA2 activity are independently associated with ERA. After immunointervention autoantibody titers against all types of oxLDL were decreased in parallel to the increase in high-density lipoprotein-cholesterol and high-density lipoprotein-Lp-PLA2 activity. We conclude that elevated autoantibody titers against oxLDL at the end of the decomposition phase of oxidation and low plasma Lp-PLA2 activity are feature characteristics of patients with ERA, suggesting an important role of these parameters in the pathophysiology of ERA as well as in the accelerated atherosclerosis observed in these patients.
机译：类风湿关节炎是一种慢性炎症性疾病，与动脉粥样硬化加速引起的心血管疾病发病率和死亡率过高有关。氧化的低密度脂蛋白（oxLDL），抗oxLDL的抗体和脂蛋白相关的磷脂酶A2（Lp-PLA2）可能在炎症和动脉粥样硬化中起重要作用。我们调查了早期类风湿关节炎（ERA）患者的血浆oxLDL和Lp-PLA2活性水平以及针对轻度oxLDL的自身抗体滴度。还确定了免疫干预对活动性疾病患者这些参数的长期影响。符合美国风湿病学会标准的58名ERA患者被纳入研究。患者接受甲氨蝶呤和泼尼松治疗。六十三名显然健康的志愿者也参加了该研究并作为对照。在氧化的滞后，扩散和分解阶段结束时，制备了三种不同类型的轻度oxLDL。通过ELISA方法测定针对所有类型的oxLDL的IgG型血清自身抗体滴度。血浆oxLDL水平和Lp-PLA2活性分别通过ELISA法和三氯乙酸沉淀法测定。与对照组相比，ERA患者在基线时表现出针对所有轻度oxLDL类型的自身抗体滴度升高，以及与高密度脂蛋白相关的总血浆Lp-PLA2和Lp-PLA2的活性较低。多元回归分析显示，在氧化分解阶段结束时，对oxLDL的自身抗体滴度升高和血浆Lp-PLA2活性低与ERA独立相关。免疫干预后，针对所有类型的oxLDL的自身抗体滴度均降低，同时高密度脂蛋白胆固醇和高密度脂蛋白Lp-PLA2活性增加。我们得出结论，在氧化分解阶段结束时针对oxLDL的自身抗体滴度升高和血浆Lp-PLA2活性低是ERA患者的特征特征，表明这些参数在ERA的病理生理学以及在加速治疗中的重要作用在这些患者中观察到动脉粥样硬化。

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