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首页> 外文会议>International Conference on Medical Physiology >Biochemical significance of autoantibody titers against oxidized low-density lipoprotein in patients with coronary heart disease
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Biochemical significance of autoantibody titers against oxidized low-density lipoprotein in patients with coronary heart disease

机译：冠心病患者氧化低密度脂蛋白的自身抗体滴度的生化意义

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Oxidative modification of LDL- which plays a key role in the development of atherosclerosis-induces immunogenic epitopes in LDL molecule, and the presence of anti-OxLDL (aOxLDL) has been demonstrated in human sera. Although its biological significance in atherogenesis is unclear and not well established. The purposes of this study were to assess whether aOxLDL is related to other inflammatory markers of possible interest in atherosclerotic development, such as C-reactive protein (CRP). Moreover, to search for any correlation with lipid profile, or creatine kinase (CK) and isoenzyme (CK-MB). Fifteen patients (10 men and 5 women; mean age 41-64 years) with unstable angina (UA). Another fifteen patients (11 men and 4 women; mean age 40-65 years) with acute myocardial infarction (AMI). Ten healthy volunteers with matched age and sex were included in this study. Laboratory investigations included: Full lipid profile, C-reactive protein (CRP), cereatine kinase (CK) and iso enzyme (CK-MB) and also troponineI as well as serum titers of auto antibodies against Oxidized LDL (aOxLDL) were assessed by ELISA. Elevated aOxLDL (antibody titers) were observed in AMI and UA than controls (418.40 ± 202.05, 287.13 ± 101.75, 182.90 ± 51.02 mU/ml respectively). The higher levels of aOxLDL and CRP were statistically significant in AMI than UA than controls (F = 10.606, P = 0.000 and F = 27.519, P = 0.000, respectively). On the other hand There was no significant correlation observed between these values (r = -.160, p = 0.568). There is no correlation between aOxLDL and lipid profile, total CK and CK-MB. Receiver operating (ROC) curve between UA and AMI revealed a cut off value = 307.5 mU/ml. There was an 8 fold increased risk of developing AMI (95% confidence interval, 1.5-42.0, p = 0.025). The elevated levels of aOxLDL may be useful for identifying Patients of higher risk for cardiac events. It may also be a marker of plaque instability to be considered in the therapeutic strategy in acute coronary syndrome.
机译：LDL-氧化修饰起着在动脉粥样硬化诱导LDL分子免疫原性表位的发展中起关键作用，和抗脂蛋白的存在（aOxLDL）已被证明在人血清。虽然在动脉粥样硬化及其生物学意义尚不清楚，并没有很好地建立。本研究的目的是评估aOxLDL是否与动脉粥样硬化的发展可能的兴趣的其它炎性标记物，如C-反应蛋白（CRP）。此外，以搜索与脂质分布，或肌酸激酶（CK）和同工酶（CK-MB）的任何相关性。 15名患者（10名男性和5名女性，平均年龄41-64岁），不稳定型心绞痛（UA）。另外15例（11名男4名女，平均年龄40-65岁）急性心肌梗死（AMI）。与匹配的年龄和性别十大健康志愿者纳入本研究。实验室检查包括：全脂质分布，C-反应蛋白（CRP），cereatine激酶（CK）和异酶（CK-MB），并且还troponineI以及抗氧化的LDL的自动抗体的血清效价（aOxLDL）通过ELISA进行评估。升高aOxLDL（抗体滴度）的AMI和UA观察比对照组（418.40±202.05，分别毫升287.13±101.75，182.90±51.02 MU /）。上级aOxLDL和CRP的在AMI有统计学显著比UA比对照组（F = 10.606，P = 0.000和F = 27.519，P = 0.000，分别地）。在另一方面有这些值之间没有观察到显著相关（r = -.160，p值= 0.568）。有aOxLDL和血脂，总CK和CK-MB之间没有相关性。 UA和AMI之间接收机操作（ROC）曲线显示的截止值= 307.5 MU / ml的。有显影AMI（95％置信区间，1.5-42.0，p值= 0.025）的8倍增加的风险。 aOxLDL的升高的水平可以是用于识别心脏事件的风险较高的患者是有用的。它也可以是斑块的不稳定性的标志物在急性冠脉综合征的治疗策略考虑。

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