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Determining autoantibodies against oxidized low-density lipoprotein, useful for diagnosis of e.g. arteriosclerosis, without interference from antibodies against native lipoprotein
Determining autoantibodies against oxidized low-density lipoprotein, useful for diagnosis of e.g. arteriosclerosis, without interference from antibodies against native lipoprotein
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机译：确定抗氧化的低密度脂蛋白的自身抗体，可用于诊断例如动脉硬化，不受天然脂蛋白抗体的干扰
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摘要
Determining autoantibodies (AAb) against oxidized low-density lipoprotein (oxLDL) in physiological fluids with simultaneous subtraction of interfering antibodies directed against native LDL or other lipids or phospholipids with similar properties, is new. Determining autoantibodies (AAb) against oxidized low-density lipoprotein (oxLDL) in physiological fluids with simultaneous subtraction of interfering antibodies directed against native LDL or other lipids or phospholipids with similar properties. First oxLDL is fixed, covalently or by adsorption, to the surface of a carrier, while native LDL (or other (phospho)lipid) is fixed similarly to a geometrically complementary carrier. The two carriers are simultaneously contacted with test fluid, e.g. serum, and then detection made by standard immunological methods, preferably by optical, electrochemical or fluorimetric measurement. Independent claims are also included for: (1) test kit for detecting AAb; and (2) microtiter plate coated with oxLDL and a complementary pin cover coated with native LDL.
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