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首页> 美国政府科技报告 >Oxidized LDL Density Lipoprotein Antibodies and Oxidized Low Density Lipoprotein-Containing Immune Complexes: Characteristics and Pathogenic Significance in Diabetes
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Oxidized LDL Density Lipoprotein Antibodies and Oxidized Low Density Lipoprotein-Containing Immune Complexes: Characteristics and Pathogenic Significance in Diabetes

机译：氧化LDL密度脂蛋白抗体和含氧化低密度脂蛋白的免疫复合物：糖尿病的特征和致病意义

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Mounting evidence suggests that two major vascular complications of diabetes mellitus, atherosclerosis and nephropathy, are pathogenically analogous processes, with atherosclemsis occurring primarily in the macrovasculature and nephropathy involving the microvasculature. Additionally, several lines of evidence point to oxidized low-density lipoprotein (oxLDL) as a major participant in both processes. OxLDL is found deposited in both types of vascular lesions, and appears to influence several events. It causes influx of macrophages, which ingest the oxLDL and are transformed into foam cells - a key component of atherosclerosis and glomemlosclerosis. OxLDL also appears to promote the proliferation of smooth muscle cells in atherosclerosis and mesangial cells in glomemlosclerosis; and expansion of the extracellular matrix in both lesions.

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