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首页> 外文会议>Recent researches in modern medicine >Biochemical significance of autoantibody titers against oxidized low- density lipoprotein in patients with coronary heart disease
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Biochemical significance of autoantibody titers against oxidized low- density lipoprotein in patients with coronary heart disease

机译：氧化型低密度脂蛋白自身抗体滴度在冠心病患者中的生化意义

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摘要

Oxidative modification of LDL- which plays a key role in the development of atherosclerosis-induces immunogenic epitopes in LDL molecule, and the presence of anti-OxLDL (aOxLDL) has been demonstrated in human sera .Although its biological significance in atherogenesis is unclear and not well established.The purposes of this study were to assess whether aOxLDL is related to other inflammatory markers of possible interest in atherosclerotic development, such as C-reactive protein (CRP). Moreover, to search for any correlation with lipid profile , or creatine kinase (CK) and isoenzyme (CK-MB) .Fifteen patients (10 men and 5 women; mean age 41-64 years) with unstable angina (UA). Another fifteen patients (11 men and 4 women; mean age 40-65 years) with acute myocardial infarction (AMI). Ten healthy volunteers with matched age and sex were included in this study. Laboratory investigations included: Full Hpid profile, C-reactive protein (CRP) ,cereatine kinase (CK) and iso enzyme (CK-MB) and also troponinel as well as serum titers of auto antibodies against Oxidized LDL (aOxLDL) were assessed by ELISA. Elevated aOxLDL (antibody titers) were observed in AMI and UA than controls (418.40 ± 202.05, 287.13 ± 101.75, 182.90 ± 51.02 mU/ml respectively). The higher levels of aOxLDL and CRP were statistically significant in AMI than UA than controls (F - 10.606, P = 0.000 and F = 27.519, P = 0.000, respectively).On the other hand There was no significant correlation observed between these values ( r = -.160 , p = 0.568 ) .There is no correlation between aOxLDL and lipid profile ,total CK and CK-MB. Receiver operating (ROC) curve between UA and AMI revealed a cut off value = 307.5 mU/ml. There was an 8 fold increased risk of developing AMI (95 % confidence interval, 1.5-42.0, p = 0.025). The elevated levels of aOxLDL may be useful for identifying Patients of higher risk for cardiac events. It may also be a marker of plaque instability to be considered in the therapeutic strategy in acute coronary syndrome.
机译：LDL的氧化修饰在动脉粥样硬化的发展中起关键作用，诱导LDL分子中的免疫原性表位，并且在人血清中已证明存在抗OxLDL（aOxLDL）。尽管其在动脉粥样硬化形成中的生物学意义尚不清楚这项研究的目的是评估aOxLDL是否与动脉粥样硬化发展中可能感兴趣的其他炎症标志物有关，例如C反应蛋白（CRP）。此外，要寻找与脂质分布或肌酸激酶（CK）和同工酶（CK-MB）的相关性。15例不稳定型心绞痛（UA）患者（10例男性和5例女性；平均年龄41-64岁）。另有15例急性心肌梗死（AMI）患者（11例男性和4例女性；平均年龄40-65岁）。这项研究包括十名年龄和性别相匹配的健康志愿者。实验室研究包括：通过ELISA评估完整的Hpid谱，C反应蛋白（CRP），神经氨酸激酶（CK）和同工酶（CK-MB）以及肌钙蛋白以及抗氧化LDL的自身抗体的血清滴度（aOxLDL） 。在AMI和UA中观察到aOxLDL（抗体滴度）升高，高于对照组（分别为418.40±202.05、287.13±101.75、182.90±51.02 mU / ml）。在AMI中，aOxLDL和CRP的水平在统计学上高于UA（分别为F-10.606，P = 0.000和F = 27.519，P = 0.000）。 r = -.160，p = 0.568）。aOxLDL与血脂谱，总CK和CK-MB之间无相关性。 UA和AMI之间的接收器操作（ROC）曲线显示截止值= 307.5 mU / ml。发生AMI的风险增加了8倍（95％置信区间，1.5-42.0，p = 0.025）。高水平的aOxLDL可能有助于识别心脏事件风险较高的患者。在急性冠脉综合征的治疗策略中也可能考虑斑块不稳定性。

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  • 来源
    《Recent researches in modern medicine》|2011年|p.463-471|共9页
  • 会议地点 Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB)
  • 作者

    MAHMOUD I. NASR; SHADEN M. HANAFY; M OSMAN; EHAB M. ABDEL-FATTAH; DALIA A; HASSAN M.;

  • 作者单位

    Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute (GEBRI), Sadat City, Menufiya University.EGYPT.;

    Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute (GEBRI), Sadat City, Menufiya University.EGYPT.;

    Department of Bioinformatics, Genetic Engineering and Biotechnology Research Institute (GEBRI), Sadat City, Menufiya University.EGYPT.;

    Department of Cardiology, Faculty of Medicine, Shebin El-Kom, Menufiya University.EGYPT.;

    Department of public health, Faculty of Medicine, Cairo University.EGYPT.;

    Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute (GEBRI), Sadat City, Menufiya University.EGYPT.;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 基础医学;
  • 关键词

    oxidised LDL; antioxidisedLDL; acute myocardial infarction; ROC curve;

    机译：氧化的低密度脂蛋白;抗氧化的LDL；急性心肌梗塞; ROC曲线;

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