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Quality by Design Approach for Development and Characterisation of Solid Lipid Nanoparticles of Quetiapine Fumarate

机译：设计和开发富马酸喹硫平固体脂质纳米颗粒的表征方法

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摘要

Quetiapine fumarate, a 2 generation anti-psychotic drug has oral bioavailability of 9% because of hepatic first pass metabolism. Reports suggest that co-administration of drugs with lipids affects their absorption pathways, enhances lymphatic transport thus bypassing hepatic first-pass metabolism resulting in enhanced bioavailability.

机译：富马酸喹硫平是一种2代抗精神病药，由于肝首过代谢，口服生物利用度为9％。报告表明，将药物与脂质共同使用会影响其吸收途径，增强淋巴运输，从而绕开肝脏首过代谢，从而提高生物利用度。

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期刊名称 Bentham Open Access
作者
Shweta Agarwal; Rayasa S. Ramachandra Murthy; Sasidharan Leelakumari Harikumar; Rajeev Garg;
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年(卷),期 -1(16),1
年度 -1
页码 -1
总页数 19
原文格式 PDF
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关键词
Quetiapine fumarate; solid lipid nanoparticles; percent entrapment efficiency; precirol ATO5; phospholipon 90G; quality by design;

机译：富马酸喹硫平;固体脂质纳米粒;包封率;precirol ATO5;磷脂90G;设计质量;

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1. Quality by Design Approach for Development and Characterisation of Solid Lipid Nanoparticles of Quetiapine Fumarate [J] . Agarwal Shweta, Murthy Rayasa S. Ramachandra, Harikumar Sasidharan Leelakumari, Current computer-aided drug design . 2020,第1期

机译：喹硫磺酸喹甲型固体脂质纳米粒子的开发和表征的设计方法
2. Solid Lipid Nanoparticles Approach for Lymphatic Targeting through Intraduodenal Delivery of Quetiapine Fumarate [J] . Yasir Mohd, Gaur Praveen Kumar, Puri Dinesh, Current drug delivery . 2018,第6期

机译：通过喹硫钾肺内递送淋巴靶向的固体脂质纳米粒子方法
3. Formulation and Evaluation of Solid Lipid Nanoparticles of Quetiapine Fumarate and Quetiapine Hemifumarate for Brain Delivery in Rat Model [J] . Lohan Shikha, Sharma Sumit, Rayasa Ramachandra Murthy Pharmaceutical Nanotechnology . 2013,第3期

机译：富马酸喹硫平和半富马酸喹硫平固体脂质纳米粒的制备及评价
4. Solid Lipid Nanoparticles Made of Self-Emulsifying Lipids for Efficient Encapsulation of Hydrophilic Substances [C] . Adriana Trapani, Delia Mandracchia, Giuseppe Tripodo, NanoInnovation -Conference and Exhibition . 2019

机译：由自乳化脂质制成的固体脂质纳米颗粒，用于有效封装亲水性物质
5. Development and Characterization of LDV Peptide Targeted Nanocarriers for Paclitaxel Delivery: A Comparative Study of Micelles, Liposomes and Solid Lipid Nanoparticles [D] . Dattani, Poonam. 2019

机译：紫杉醇传递的LDV肽靶向纳米载体的开发和表征：胶束，脂质体和固体脂质纳米颗粒的比较研究。
6. Development of Pomegranate Extract-Loaded Solid LipidNanoparticles: Quality by Design Approach to Screen the VariablesAffecting the Quality Attributes and Characterization [O] . Noha Badawi, Khalid El-Say, Dalia Attia, 2020

机译：石榴提取物加载固体脂质的发展纳米粒子：通过设计方法来筛选变量的质量影响质量属性和表征
7. Quality by Design Approach for Development and Characterisation of Solid Lipid Nanoparticles of Quetiapine Fumarate [O] . Shweta Agarwal, Rayasa S. Ramachandra Murthy, Sasidharan Leelakumari Harikumar, 2020

机译：喹硫磺酸喹甲型固体脂质纳米粒子的开发和表征的设计方法

Quality by Design Approach for Development and Characterisation of Solid Lipid Nanoparticles of Quetiapine Fumarate

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