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首页> 美国卫生研究院文献>BioMed Research International >The Bidirectional Interactions between Resveratrol and Gut Microbiota: An Insight into Oxidative Stress and Inflammatory Bowel Disease Therapy
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The Bidirectional Interactions between Resveratrol and Gut Microbiota: An Insight into Oxidative Stress and Inflammatory Bowel Disease Therapy

机译：白藜芦醇和肠道菌群之间的双向相互作用：氧化应激和炎症性肠病治疗的见解。

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Dysbiosis and oxidative stress in the gut have contributed to the progression of intestinal inflammatory bowel disease (IBD). The current study has reported that enteric bacteria mediate redox homeostasis through the regulation of reactive oxygen species (ROS) production. Resveratrol, one of the most abundant polyphenols, with poor oral bioavailability, is considered as a scavenger of ROS and other free radicals. Recent studies have shown that resveratrol effectively enhances the growth of Lactococcus lactis and inhibits the growth of Enterococcus faecalis. (1) In terms of the two-way relationship between gut microbiota and resveratrol, resveratrol modulates gut microbiota; (2) in terms of resveratrol biotransformation by gut microbiota, we speculate that gut microbiota could be a target of resveratrol to maintain gut homeostasis. Here, we reviewed the current researches about the cellular signaling pathways in intestinal epithelial cells triggered by gut microbiota in response to oxidative stress. These results suggest that the modulation of the gut microbiota through resveratrol supplementation appears as a promising potential approach for the therapy of inflammatory bowel disease.
机译：肠道中的营养不良和氧化应激促进了肠道炎性肠病（IBD）的发展。目前的研究报道，肠细菌通过调节活性氧（ROS）的产生来介导氧化还原稳态。白藜芦醇是最丰富的多酚之一，口服生物利用度较差，被认为是ROS和其他自由基的清除剂。最近的研究表明，白藜芦醇可有效增强乳酸乳球菌的生长并抑制粪肠球菌的生长。 （1）就肠道菌群与白藜芦醇之间的双向关系而言，白藜芦醇调节肠道菌群； （2）就肠道菌群对白藜芦醇的生物转化而言，我们推测肠道菌群可能是白藜芦醇维持肠道稳态的靶标。在这里，我们综述了当前肠道肠上皮细胞中细胞信号通路的研究，这些细胞是由肠道菌群响应氧化应激而触发的。这些结果表明，通过补充白藜芦醇来调节肠道菌群是治疗炎症性肠病的一种有前途的潜在方法。

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