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GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway

机译：GDNF通过其受体亚基NCAM和ERK1 / 2信号通路刺激培养的小鼠未成熟支持细胞的增殖

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BackgroundThe proliferation and final density of Sertoli cells in the testis are regulated by hormones and local factors. Glial cell line-derived neurotrophic factor (GDNF), a distantly related member of the transforming growth factor-β superfamily, and its receptor subunits GDNF family receptor alpha 1 (GFRα1), RET tyrosine kinase, and neural cell adhesion molecule (NCAM) have been reported to be expressed in the testis and involved in the regulation of proliferation of immature Sertoli cells (ISCs). However, the expression patterns of these receptor subunits and the downstream signaling pathways have not been addressed in ISCs.

机译：背景睾丸支持细胞的增殖和最终密度受激素和局部因素调节。胶质细胞源性神经营养因子（GDNF）是转化生长因子-β超家族的远亲成员，其受体亚基GDNF家族受体α1（GFRα1），RET酪氨酸激酶和神经细胞粘附分子（NCAM）具有据报道其在睾丸中表达并参与未成熟Sertoli细胞（ISC）的增殖调控。但是，这些受体亚基的表达模式和下游信号传导途径尚未在ISC中解决。

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期刊名称 BMC Cell Biology
作者
Yongguang Yang; Chunsheng Han;
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作者单位

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年(卷),期 2001(11),
年度 2001
页码 78
总页数 10
原文格式 PDF
正文语种
中图分类细胞生物学;
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专利

1. GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway [J] . Yongguang Yang, Chunsheng Han BMC Cell Biology . 2010,第1期

机译：GDNF通过其受体亚基NCAM和ERK1 / 2信号通路刺激培养的小鼠未成熟支持细胞的增殖
2. WNT/β-catenin-signaling pathway stimulates the proliferation of cultured adult human Sertoli cells via upregulation of C-myc expression [J] . Reproductive sciences . 2012,第11期

机译：WNT /β-catenin信号通路通过上调C-myc表达刺激成年人支持细胞的增殖
3. 17β-Estradiol Regulates Cultured Immature Boar Sertoli Cell Proliferation via the cAMP-ERK1/2 Pathway and the Estrogen Receptor β [J] . WANG Xian-zhong, ZHAO Bo-chuan, ZHOU Yu-lan, 中国农业科学：英文版 . 2010,第008期

机译：17β-雌二醇通过cAMP-ERK1 / 2途径和雌激素受体β调节培养的未成熟公猪支持细胞的增殖
4. Sustained Static Pressure Stimulates Proliferation of Cultured Smooth Muscle Cells Via the Extracellular Signal-Regulated Kinase Pathway [C] . D.X. Luo, C.L. Xia, S.Y. He, World Congress on Heart Disease . 2007

机译：持续的静压刺激通过细胞外信号调节激酶途径刺激培养的平滑肌细胞的增殖
5. Signaling pathway from the A(2B) adenosine receptor to extracellular signal-regulated kinases (ERK1/2) in human umbilical vein endothelial cells (HUVEC) and its role in HUVEC proliferation [D] . Fang, Ying 2006

机译：从A（2B）腺苷受体到人脐静脉内皮细胞（HUVEC）中细胞外信号调节激酶（ERK1 / 2）的信号通路及其在HUVEC增殖中的作用
6. GDNF Induces CREB-1 ATF-1 and CREM-1 Phosphorylation and Up-regulates c-fos Transcription via the Ras/ERK1/2 Pathway to Promote Mouse Spermatogonial Stem Cell Proliferation [O] . Zuping He, Jiji Jiang, Maria Kokkinaki, -1

机译：GDNF诱导CREB-1ATF-1和CREM-1磷酸化并通过Ras / ERK1 / 2途径上调c-fos转录从而促进小鼠精原干细胞的增殖。
7. GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway [O] . Yongguang Yang, Chunsheng Han 2010

机译：GDNF通过其受体亚基NCAM和ERK1 / 2信号通路刺激培养的小鼠未成熟支持细胞的增殖
8. Ligand-Stimulated Signaling Events in Immature CD4+CD8+Thymocytes ExpressingCompetent T-Cell Receptor Complexes [R] . Nakayama, T., Samelson, L. E., Nakayama, Y., 1991

机译：未成熟CD4 + CD8 +胸腺细胞中的配体刺激信号事件表达感受态T细胞受体复合物

GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway

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