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Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish

机译：NCS-1结合蛋白的蛋白质组学和功能分析揭示了斑马鱼内耳发育所需的新信号通路

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BackgroundThe semicircular canals, a subdivision of the vestibular system of the vertebrate inner ear, function as sensors of angular acceleration. Little is currently known, however, regarding the underlying molecular mechanisms that govern the development of this intricate structure. Zebrafish represent a particularly tractable model system for the study of inner ear development. This is because the ear can be easily visualized during early embryogenesis, and both forward and reverse genetic techniques are available that can be applied to the discovery of novel genes that contribute to proper ear development. We have previously shown that in zebrafish, the calcium sensing molecule neuronal calcium sensor-1 (NCS-1) is required for semicircular canal formation. The function of NCS-1 in regulating semicircular canal formation has not yet been elucidated.

机译：背景技术半圆形运河是脊椎动物内耳前庭系统的一个细分部分，用作角加速度传感器。然而，对于控制这种复杂结构发展的潜在分子机制，目前知之甚少。斑马鱼代表了一种特别易处理的模型系统，用于研究内耳发育。这是因为在早期胚胎发生过程中可以很容易地看到耳朵，并且可以使用正向和反向遗传技术来发现有助于正常耳朵发育的新基因。先前我们已经表明，在斑马鱼中，钙感应分子神经元钙传感器1（NCS-1）是半圆形管形成所必需的。 NCS-1在调节半规管形成中的功能尚未阐明。

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期刊名称 BMC Neuroscience
作者
Jessica A Petko; Nadine Kabbani; Colleen Frey; Matthew Woll; Katharine Hickey; Michael Craig; Victor A Canfield; Robert Levenson;
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作者单位

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年(卷),期 1935(10),
年度 1935
页码 27
总页数 15
原文格式 PDF
正文语种
中图分类神经科学;
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专利

1. Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish [J] . Jessica A Petko, Nadine Kabbani, Colleen Frey, BMC Neuroscience . 2009,第1期

机译：NCS-1结合蛋白的蛋白质组学和功能分析揭示了斑马鱼内耳发育所需的新信号通路
2. Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells [J] . Danica D. Wiredja, Caroline O. Tabler, Daniela M. Schlatzer, Retrovirology . 2018,第1期

机译：CCR5-Tropic HIV-1信号的全局磷蛋白蛋白质揭示了细胞蛋白质生产途径的重新编程，并将P70-S6K1和MK2鉴定为CD4 + T细胞最佳感染所需的HIV响应激酶
3. A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway [J] . Alena Sala?ová, Chika Yokota, David Potě?il, Molecular neurodegeneration . 2017,第1期

机译：LRRK2结合伴侣的蛋白质组学分析揭示了与WNT / PCP途径的多个信号传导成分的相互作用
4. HDX-TIMS-MS and molecular dynamics reveal folding pathways in DNA-binding proteins [C] . Emily Schenk, Frederic Nau, Genevieve Gozo, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：HDX-TIMS-MS和分子动力学在DNA结合蛋白中显示折叠途径
5. Functional proteomic approaches for the analysis of a dynamic signaling pathway. [D] . Dembowy, Joanna. 2005

机译：用于动态信号通路分析的功能蛋白质组学方法。
6. Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells [O] . Danica D. Wiredja, Caroline O. Tabler, Daniela M. Schlatzer, 2018

机译：CCR5-tropic HIV-1信号转导的全球磷酸蛋白质组学揭示了细胞蛋白生产途径的重编程并将p70-S6K1和MK2鉴定为CD4 + T细胞最佳感染所需的HIV反应激酶
7. Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish [O] . Jessica A Petko, Nadine Kabbani, Colleen Frey, 2009

机译：NCS-1结合蛋白的蛋白质组学和功能分析揭示了斑马鱼内耳发育所需的新信号通路
8. Small Scale Proteomics Approach for Identifying Proteins Regulated by the Breast Tumor Kinase BRK Signal Transduction Pathway. [R] . Tyner, A. L. 2002

机译：用于鉴定由乳腺肿瘤激酶BRK信号转导途径调节的蛋白质的小规模蛋白质组学方法。

Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish

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