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首页> 美国卫生研究院文献>British Heart Journal >Effect of raised plasma β endorphin concentrations on peripheral pain and angina thresholds in patients with stable angina
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Effect of raised plasma β endorphin concentrations on peripheral pain and angina thresholds in patients with stable angina

机译：血浆β-内啡肽浓度升高对稳定型心绞痛患者外周痛和心绞痛阈值的影响

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OBJECTIVE—To determine whether changes in plasma concentrations of β endorphins alter angina threshold and peripheral pain threshold in patients with stable angina.
DESIGN—Latin square design comparison of angina thresholds by exercise treadmill test and peripheral pain thresholds using a radiant heat source in eight patients with stable angina under control conditions, after stimulation of pituitary β endorphin release by ketoconazole, after suppression of pituitary β endorphin release by dexamethasone, and after blockade of opioid receptors by intravenous naloxone.
RESULTS—An approximately fivefold increase in circulating concentrations of β endorphins was found after administration of ketoconazole (mean (SEM): 13.9 (1.2) v 73.8 (6.2) pg/ml; p < 0.05), which was associated with an increase in peripheral pain threshold to a radiant heat source (time to onset of pain perception 72 (19) v 123 (40) seconds; p < 0.05), but no significant difference in angina threshold. A reduction in circulating concentrations of β endorphins after pretreatment with dexamethasone was statistically non-significant (13.9 (1.2) v 9.0 (1.5) pg/ml; NS) and was not associated with any change in either peripheral pain or angina thresholds. No effects were seen after blockade of opioid receptors by previous administration of intravenous naloxone.
CONCLUSIONS—Increased plasma concentrations of β endorphins alter peripheral pain threshold but not angina threshold in patients with stable angina pectoris.


Keywords: β endorphin; angina; pain
机译：目的—确定稳定型心绞痛患者的血浆β-内啡肽浓度变化是否会改变心绞痛阈值和外周痛阈值。
设计—通过运动跑步机测试和辐射热产生的外周痛阈值的拉丁方设计比较心绞痛阈值在控制条件下，酮康唑刺激垂体β-内啡肽释放，地塞米松抑制垂体β-内啡肽释放，静脉内纳洛酮阻断阿片受体阻断作用后，八名稳定型心绞痛患者的血脂来源。
结果—大约五倍服用酮康唑后发现β内啡肽的循环浓度增加（平均值（SEM）：13.9（1.2）v 73.8（6.2）pg / ml; p <0.05），这与辐射引起的周围疼痛阈值增加有关热源（开始疼痛感知的时间72（19）v 123（40）秒; p <0.05），但心绞痛阈值无显着差异。经地塞米松预处理后，β内啡肽的循环浓度降低在统计学上无统计学意义（13.9（1.2）v 9.0（1.5）pg / ml; NS），并且与周围疼痛或心绞痛阈值的任何改变无关。先前静脉内给予纳洛酮对阿片受体的阻滞作用未见效果。
结论—稳定型心绞痛患者血浆β内啡肽浓度的增加改变了外周痛阈值，但不会改变心绞痛阈值。

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