The antimicrobial properties of some α-amino-oxy-acids α-amino-oxy-hydrazides alkoxyamines alkoxydiguanides and their derivatives

机译：一些α-氨基氧基酸α-氨基氧基酰肼烷氧基胺烷氧基二胍及其衍生物的抗菌性能

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A series of compounds containing an amino-oxy-group has been examined for antibacterial and antifungal activity. The amino-oxy-acids and the alkoxyamines showed little activity, but the hydrazides, notably the amino-oxydodecyl and the amino-oxytetradecyl compounds, had appreciable activity against Staphylococcus aureus. The alkoxydiguanides showed considerable bactericidal activity in vitro against Gram-positive and Gram-negative organisms and some activity against Mycobacterium tuberculosis. The most active compounds were those with a chain containing 10 to 14 carbon atoms, but the activity was considerably reduced in the presence of serum. They were also active against the few fungi tested. The most active compound, decyloxydiguanide, was moderately toxic when administered intraperitoneally to mice and no therapeutic activity could be demonstrated against an intraperitoneal injection of Streptococcus pyogenes administered 15 min. previously.

机译：已经检查了一系列含有氨基氧基的化合物的抗菌和抗真菌活性。氨基氧基酸和烷氧基胺几乎没有活性，但是酰肼，特别是氨基氧基十二烷基和氨基氧基十四烷基化合物，对金黄色葡萄球菌具有明显的活性。烷氧基二胍在体外对革兰氏阳性和革兰氏阴性生物具有相当大的杀菌活性，对结核分枝杆菌也有一定活性。活性最高的化合物是那些具有10至14个碳原子链的化合物，但是在存在血清的情况下活性大大降低。它们还对少数经过测试的真菌具有活性。当给小鼠腹膜内给药时，活性最高的化合物癸氧基二胍具有中等毒性，并且对于腹膜内注射化脓性链球菌15分钟，未表现出治疗活性。先前。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
S. A. Price; P. Mamalis; D. McHale; J. Green;
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年(卷),期 1960(15),2
年度 1960
页码 243–246
总页数 4
原文格式 PDF
正文语种
中图分类药学;
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机译：一些α-氨基 - 氧 - 酸，α-氨基 - 酰肼，烷氧基胺，烷氧基二胍及其衍生物的抗微生物性质

The antimicrobial properties of some α-amino-oxy-acids α-amino-oxy-hydrazides alkoxyamines alkoxydiguanides and their derivatives

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