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首页> 美国卫生研究院文献>British Journal of Pharmacology and Chemotherapy >Effects of chronic vitamin E deficiency on vascular function--a study of sympathetic nerves smooth muscle and endothelium of the mesenteric arterial bed of the rat.
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Effects of chronic vitamin E deficiency on vascular function--a study of sympathetic nerves smooth muscle and endothelium of the mesenteric arterial bed of the rat.

机译：慢性维生素E缺乏对血管功能的影响-大鼠肠系膜动脉床交感神经平滑肌和内皮的研究。

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1. Male rats were deprived as weanlings of dietary vitamin E for 2, 4, 6, 10 and 12 months. Mesenteric arterial beds from these rats and from age-matched controls were isolated and perfused with Krebs solution at a constant flow rate (5 ml min-1). The function of perivascular sympathetic nerves, smooth muscle and endothelium was assessed. 2. At 12 months vitamin E deficient rats exhibited the characteristic symptoms of vitamin E deficiency, namely poor coat condition, muscle wasting, kyphoscoliosis and impaired gait. In the isolated mesenteric arterial bed electrical field stimulation (EFS) of perivascular nerves (4-32 Hz, 90 V, 1 ms, for 30 s) elicited frequency-dependent vasoconstrictor responses which were unaffected by vitamin E deficiency except at 12 months, at which age responses were significantly greater than those of the controls at 24 and 32 Hz (P < 0.01). 3. Exogenous noradrenaline (NA; 0.15-500 nmol) elicited dose-dependent vasoconstriction which was similar in vitamin E-deficient and control preparations at all ages. Potassium chloride (0.15 mmol) also produced similar vasoconstrictor responses in vitamin E-deficient and control preparations at each age. 4. Tone of the preparations was raised by continuous perfusion with methoxamine (4-70 microM), producing similar increases in perfusion pressure in vitamin E-deficient and control preparations at each age. Endothelium-dependent dose-dependent vasodilatation to adenosine 5'-triphosphate was significantly impaired in mesenteric arterial beds from 12 month-old vitamin E-deficient rats compared with the controls (P < 0.05). Relaxation to acetylcholine was not significantly different at any age. 5. Endothelium-independent vasodilatation to sodium nitroprusside was similar in vitamin E-deficient rats and age-matched controls. 6. These results suggest that long term (12 months) deprivation of dietary vitamin E may impair endothelial function in mesenteric arteries of the rat. Sympathetic perivascular nerve constrictor function was increased at 12 months. There were no functionally expressed changes in the vascular smooth muscle, which appears to be more resilient to the effects of oxidative stress in vitamin E deficiency.
机译：1.断奶仔鼠饮食中的维生素E为2、4、6、10和12个月。分离这些大鼠和年龄相匹配的对照组的肠系膜动脉床，并以恒定流速（5 ml min-1）灌注Krebs溶液。评估了血管周围交感神经，平滑肌和内皮的功能。 2.缺乏维生素E的大鼠在12个月时表现出维生素E缺乏的特征性症状，即：外套状况差，肌肉消瘦，脊柱后凸畸形和步态受损。在孤立的肠系膜动脉床电场周围神经（4-32 Hz，90 V，1 ms，30 s）的电场刺激（EFS）引起频率依赖性血管收缩反应，该反应不受维生素E缺乏的影响，除非在12个月，在24和32 Hz时，年龄响应显着大于对照组（P <0.01）。 3.外源性去甲肾上腺素（NA； 0.15-500nmol）引起剂量依赖性血管收缩，在所有年龄的维生素E缺乏和对照制剂中相似。在每个年龄段，维生素E缺乏和对照制剂中的氯化钾（0.15 mmol）也会产生类似的血管收缩反应。 4.通过连续灌注甲恶胺（4-70 microM）来提高制剂的色调，在每个年龄的维生素E缺乏和对照制剂中，灌注压力也会产生类似的增加。与对照组相比，在12个月大维生素E缺乏症大鼠的肠系膜动脉床中，对5'-三磷酸腺苷的内皮依赖性剂量依赖性血管舒张作用显着受损（P <0.05）。对乙酰胆碱的放松在任何年龄都没有显着差异。 5.在维生素E缺乏的大鼠和年龄匹配的对照组中，非依赖性内皮舒张血管扩张至硝普钠的作用相似。 6.这些结果表明，长期（12个月）缺乏饮食中的维生素E可能会损害大鼠肠系膜动脉的内皮功能。 12个月时交感性血管周围神经收缩功能增加。血管平滑肌没有功能性表达的变化，似乎对维生素E缺乏症中的氧化应激的影响更具弹性。

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