Nphe1-Nociceptin (1-13)-NH2 a nociceptin receptor antagonist reverses nociceptin-induced spatial memory impairments in the Morris water maze task in rats

机译：Nphe1 -Nociceptin（1-13）-NH2是一种伤害感受器受体拮抗剂可逆转伤害感受器引起的大鼠莫里斯水迷宫任务中的空间记忆障碍

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摘要

class="enumerated" style="list-style-type:decimal">The present study was undertaken to investigate the effects of the novel nociceptin receptor antagonist, [Nphe¹]-Nociceptin (1-13)-NH2 (bilateral intrahippocampal injection, 50 nmole rat⁻¹) on purported nociceptin-induced (bilateral intrahippocampal injection, 5 nmole rat⁻¹) deficits in spatial learning in the rat Morris water maze task. In addition, experiments were performed in an ‘open field' to investigate possible peptide-induced changes in exploratory behaviour.Nociceptin significantly impaired the ability of the animal to locate the hidden platform throughout training (P<0.001 versus control group).Pretreatment with [Nphe¹]-Nociceptin (1-13)-NH2 significantly blocked nociceptin-induced impairment of spatial learning (P<0.001 versus nociceptin group).A probe trial revealed that vehicle-treated animals spent more time in the quadrant that had previously contained the hidden platform, whereas nociceptin-treated animals did not spend more time in any one quadrant.Learning impairments were not attributable to non-specific deficits in motor performance or change in exploratory behaviour.Taken together, our results reveal that [Nphe¹]-Nociceptin (1-13)-NH2 represents an effective and useful in vivo antagonist at the nociceptin receptors involved in learning and memory.

机译：class =“ enumerated” style =“ list-style-type：decimal”> <！-list-behavior =枚举前缀-word = mark-type = decimal max-label-size = 0-> 本研究旨在研究新型Nociceptin受体拮抗剂[Nphe ^{1 ]-Nociceptin（1-13）-NH2（双侧海马腔内注射，50μmol摩尔大鼠^{-1 < / sup>）据称是伤害性感受态诱导的大鼠（海马双侧注射，5μmol鼠^{-1 ）在Morris水迷宫任务中的空间学习缺陷。此外，在“开放领域”中进行了实验，以调查可能的肽诱导的探索行为的变化。 Nociceptin显着削弱了动物在整个训练过程中定位隐藏平台的能力（P <0.001与对照组。 [Nphe ^{1 ]-Nociceptin（1-13）-NH2预处理可显着抑制伤害感受肽诱导的空间学习障碍（与伤害感受肽组相比，P <0.001）一项探针试验表明，接受媒介物治疗的动物在以前包含隐藏平台的象限中花费了更多时间，而接受伤害感受素治疗的动物在任何一个象限中都没有花费更多的时间。学习障碍并非归因于运动表现的非特定性缺陷或探索性行为的改变。我们的研究结果表明，[Nphe ^{1 ]-Nociceptin（ 1-13）-NH2代表与李尔有关的Nociceptin受体的有效体内拮抗剂和记忆。}}}}}

著录项

期刊名称 British Journal of Pharmacology and Chemotherapy
作者
J P Redrobe; G Calo; R Guerrini; D Regoli; R Quirion;
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作者单位

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年(卷),期 2000(131),7
年度 2000
页码 1379–1384
总页数 6
原文格式 PDF
正文语种
中图分类药学;
关键词
Nociceptin/orphanin FQ nociceptin receptor antagonist spatial learning hippocampus;

机译：Nociceptin / orphanin FQ;nociceptin受体拮抗剂;空间学习;海马;

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专利

1. Nphe(1))-Nociceptin (1-13)-NH(2), a nociceptin receptor antagonist, reverses nociceptin-induced spatial memory impairments in the Morris water maze task in rats. [J] . RedrobeJP, CaloG, GuerriniR, British Journal of Pharmacology . 2000,第7期

机译：Nphe（1））-Nociceptin（1-13）-NH（2），一种伤害感受素受体拮抗剂，逆转了伤害感受态引起的大鼠莫里斯水迷宫任务中的空间记忆障碍。
2. The selective orexin 1 receptor antagonist SB-334867-A impairs acquisition and consolidation but not retrieval of spatial memory in Morris water maze. [J] . Akbari E, Naghdi N, Motamedi F Peptides: An International Journal . 2007,第3期

机译：选择性orexin 1受体拮抗剂SB-334867-A会损害Morris水迷宫的获取和巩固，但不会损害其空间记忆。
3. The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone. [J] . Horisawa T, Ishibashi T, Nishikawa H, Behavioural Brain Research: An International Journal . 2011,第1期

机译：5-羟色胺5-HT7和5-HT1A受体选择性拮抗剂在大鼠被动回避和莫里斯水迷宫试验中对MK-801诱导的学习和记忆障碍的影响：新型非典型抗精神病药卢拉西酮的有益机理的机械意义。
4. Effects of haloperidol on MK-801-induced memory deterioration in the Morris water maze and radial-arm maze tests in mice [C] . Mutlu O., Ulak G., Celikyurt I., European Congress of Pharmacology . 2012

机译：氟哌啶醇对小鼠MORRIS水迷宫和径向臂迷宫试验MK-801诱导的记忆劣化的影响
5. Effect of prenatal phenytoin exposure in rats on forms of spatial and non-spatial learning and memory as determined by the Morris water maze and its modifications. [D] . Schilling, Mary Ann. 1996

机译：莫里斯水迷宫及其修饰所确定的大鼠产前苯妥英钠暴露对空间和非空间学习记忆形式的影响。
6. Characterization of Nphe1nociceptin(1-13)NH2 a new selective nociceptin receptor antagonist [O] . Girolamo Calo, Remo Guerrini, Raffaella Bigoni, 2000

机译：新型选择性伤害感受器受体拮抗剂Nphe1 nociceptin（1-13）NH2的表征
7. [Nphe1]-Nociceptin (1-13)-NH2, a nociceptin receptor antagonist, reverses nociceptin-induced spatial memory impairments in the Morris water maze task in rats [O] . Redrobe, J P, Calo, G, Guerrini, R, 2000

机译：[Nphe1] -Nociceptin（1-13）-NH2是一种伤害感受器受体拮抗剂，可逆转伤害感受器引起的大鼠莫里斯水迷宫任务中的空间记忆障碍
8. Hyperthermia Impairs Retention of an Overtrained Spatial Task in the Morris Water Maze [R] . Rauch, T. M., Welch, D. I., Gallego, L. 1988

机译：热疗损害莫里斯水迷宫中过度训练的空间任务的保留

Nphe1-Nociceptin (1-13)-NH2 a nociceptin receptor antagonist reverses nociceptin-induced spatial memory impairments in the Morris water maze task in rats

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