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Modulation of mouse gastrointestinal motility by allyl isothiocyanate a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects

机译：异硫氰酸烯丙酯（十字花科植物（十字花科）的一种成分）对小鼠胃肠运动的调节作用：TRPA1独立作用的证据

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摘要

BACKGROUND AND PURPOSEAllyl isothiocyanate (AITC, mustard oil), a constituent of many common cruciferous vegetables (Brassicaceae), activates transient receptor potential of ankyrin type-1 (TRPA1) channels, claimed to regulate gastrointestinal contractility. In this study, we have investigated the effect of AITC on intestinal motility.

机译：背景和目的异硫氰酸烯丙酯（AITC，芥子油），是许多常见十字花科蔬菜（十字花科）的成分，可激活1型锚蛋白（TRPA1）通道的瞬时受体电位，据称可调节胃肠道收缩力。在这项研究中，我们研究了AITC对肠蠕动的影响。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
Raffaele Capasso; Gabriella Aviello; Barbara Romano; Francesca Borrelli; Luciano De Petrocellis; Vincenzo Di Marzo; Angelo A Izzo;
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作者单位

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年(卷),期 2012(165),6
年度 2012
页码 1966–1977
总页数 12
原文格式 PDF
正文语种
中图分类药学;
关键词
allyl isothiocyanate colon gastrointestinal transit ileum intestinal motility mustard oil transient receptor potential (TRP) channels TRPA1;

机译：异硫氰酸烯丙酯;结肠;胃肠道;回肠;肠蠕动;芥子油;瞬时受体电位（TRP）通道;TRPA1;

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专利

1. Modulation of carcinogen-metabolising cytochromes P450 in human liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables. [J] . Konsue N, Ioannides C Toxicology: An International Journal Concerned with the Effects of Chemicals on Living Systems . 2010,第3期

机译：化学预防性植物化学异硫氰酸苯乙酯（十字花科蔬菜的成分）对人肝中致癌物质代谢细胞色素P450的调节。
2. Chemopreventative Potential of the Cruciferous Vegetable Constituent Phenethyl Isothiocyanate in a Mouse Model of Prostaten Cancer [J] . Shivendra V. Singh JNCI: Journal of the National Cancer Institute . 2011,第7期

机译：前列腺癌小鼠模型中十字花科蔬菜成分异硫氰酸苯乙酯的化学预防潜力。
3. Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer. [J] . Powolny AA, Bommareddy A, Hahm ER, Journal of the National Cancer Institute . 2011,第7期

机译：十字花科蔬菜成分苯乙基异硫氰酸酯在前列腺癌小鼠模型中的化学预防潜力。
4. Mitochondria as an Early Target in Prostate Cancer Destruction Mediated by an Isothiocyanate from Cruciferous Vegetables [C] . J. W. Chiao, Anastasia Beklemisheva, Jean Feng, Microscopy Society of America Annual Meeting;Microanalysis Society Annual meeting;International Metallographic Society Annual meeting . 2012

机译：线粒体是十字花科蔬菜中异硫氰酸盐介导的前列腺癌破坏的早期靶标。
5. Modulation of prostate and pancreatic PhIP-DNA adducts by consumption of cruciferous and apiaceous vegetables in male Wistar rats. [D] . Warnert, Marissa A. 2013

机译：雄性Wistar大鼠食用十字花科和豆科蔬菜可调节前列腺和胰腺PhIP-DNA加合物。
6. Chemopreventative Potential of the Cruciferous Vegetable Constituent Phenethyl Isothiocyanate in a Mouse Model of Prostate Cancer [O] . Anna A. Powolny, Ajay Bommareddy, Eun-Ryeong Hahm, -1

机译：前列腺癌的小鼠模型中十字花科蔬菜成分异硫氰酸苯乙酯的化学预防潜力。
7. Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables: evidence for TRPA1-independent effects [O] . Capasso R., Aviello G., Romano B., 2012

机译：异硫氰酸烯丙酯（十字花科蔬菜的成分）对小鼠胃肠动力的调节：TRpa1非依赖性作用的证据

Modulation of mouse gastrointestinal motility by allyl isothiocyanate a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects

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