Properties of human brain sodium channel α-subunits expressed in HEK293 cells and their modulation by carbamazepine phenytoin and lamotrigine

机译：人脑钠通道α亚基在HEK293细胞中表达的特性及其对卡马西平苯妥英钠和拉莫三嗪的调节作用

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摘要

Background and purposeVoltage-activated Na⁺ channels contain one distinct α-subunit. In the brain NaV1.1, NaV1.2, NaV1.3 and NaV1.6 are the four most abundantly expressed α-subunits. The antiepileptic drugs (AEDs) carbamazepine, phenytoin and lamotrigine have voltage-gated Na⁺ channels as their primary therapeutic targets. This study provides a systematic comparison of the biophysical properties of these four α-subunits and characterizes their interaction with carbamazepine, phenytoin and lamotrigine.

机译：背景和目的电压激活的Na ^{+ 通道包含一个不同的α-亚基。在大脑中，NaV1.1，NaV1.2，NaV1.3和NaV1.6是四个表达最丰富的α亚基。抗癫痫药卡马西平，苯妥英钠和拉莫三嗪以电压门控的Na ^{+ 通道为主要治疗靶点。该研究提供了这四个α-亚基的生物物理特性的系统比较，并表征了它们与卡马西平，苯妥英钠和拉莫三嗪的相互作用。}}

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
Xin Qiao; Guangchun Sun; Jeffrey J Clare; Taco R Werkman; Wytse J Wadman;
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作者单位

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年(卷),期 2014(171),4
年度 2014
页码 1054–1067
总页数 14
原文格式 PDF
正文语种
中图分类药学;
关键词
sodium channel epilepsy carbamazepine phenytoin lamotrigine antiepileptic drug;

机译：钠通道;癫痫;卡马西平;苯妥英钠;拉莫三嗪;抗癫痫药;

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专利

1. Carbamazepine and topiramate modulation of transient and persistent sodium currents studied in HEK293 cells expressing the Na(v)1.3 alpha-subunit. [J] . Sun GC, Werkman TR, Battefeld A, Epilepsia: Journal of the International League against Epilepsy . 2007,第4期

机译：卡马西平和托吡酯对瞬时和持续钠电流的调制在表达Na（v）1.3α亚基的HEK293细胞中进行了研究。
2. Functional modulation of human brain Na(v)1.3 sodium channels, expressed in mammalian cells, by auxiliary beta1, beta2 and beta3 subunits. [J] . Meadows L, Chen Y, Powell A, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2002,第3期

机译：人脑Na（v）1.3钠通道的功能调节，通过辅助beta1，beta2和beta3亚基在哺乳动物细胞中表达。
3. Functional Expression of GFP-linked Human Heart Sodium Channel (hH1) and Subcellular Localization of the a Subunit in HEK293 Cells and Dog Cardiac Myocytes [J] . T. Zimmer, C. Biskup, S. Dugarmaa, The Journal of Membrane Biology . 2002,第1期

机译：GFP链接的人心脏钠通道（hH1）的功能表达和HEK293细胞和犬心肌细胞中亚基的亚细胞定位
4. Method Development for the Determination of Lamotrigine, Topiramate, Phenytoin, and Phenobarbital in Human Serum Using Isotope-Dilution Liquid Chromatography-Mass Spectrometry [C] . Susan S.-C. Tai, Jocelyn L. Prendergast, Chia-Yi Yeh, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：使用同位素稀释液相色谱 - 质谱法测定乳草胺，托吡酯，苯妥林和苯甲脂肪植物中的苯甲吡啶，吡啶酸盐和苯巴罗布
5. Biophysical characterization of sodium(v)1.7 and sodium(v)1.8 rat isoforms of the voltage gated sodium channels from dorsal root ganglions: Regulation by auxiliary beta-subunits and by protein kinase A and C. [D] . Vijayaragavan, Kausalia. 2004

机译：背根神经节的电压门控钠通道的钠（v）1.7和钠（v）1.8大鼠亚型的生物物理特征：辅助β亚基和蛋白激酶A和C的调节。
6. Functional Expression of Rat Nav1.6 Voltage-Gated Sodium Channels in HEK293 Cells: Modulation by the Auxiliary β1 Subunit [O] . Bingjun He, David M. Soderlund -1

机译：大鼠Nav1.6电压门控钠通道在HEK293细胞中的功能表达：辅助β1亚基的调节。
7. Properties of human brain sodium channel α-subunits expressed in HEK293 cells and their modulation by carbamazepine, phenytoin and lamotrigine [O] . Qiao, X., Sun, G., Clare, J.J., 2014

机译：人脑钠通道α亚基在HEK293细胞中表达的特性及其对卡马西平，苯妥英钠和拉莫三嗪的调节作用

Properties of human brain sodium channel α-subunits expressed in HEK293 cells and their modulation by carbamazepine phenytoin and lamotrigine

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