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首页> 美国卫生研究院文献>British Medical Journal >Respiratory morbidity 10 years after the Union Carbide gas leak at Bhopal: a cross sectional survey. The International Medical Commission on Bhopal.
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Respiratory morbidity 10 years after the Union Carbide gas leak at Bhopal: a cross sectional survey. The International Medical Commission on Bhopal.

机译：博帕尔联合碳化物气体泄漏十年后的呼吸道疾病：一项横断面调查。博帕尔国际医学委员会。

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OBJECTIVE: To examine the role of exposure to the 1984 Bhopal gas leak in the development of persistent obstructive airways disease. DESIGN: Cross sectional survey. SETTING: Bhopal, India. SUBJECTS: Random sample of 454 adults stratified by distance of residence from the Union Carbide plant. MAIN OUTCOME MEASURES: Self reported respiratory symptoms; indices of lung function measured by simple spirometry and adjusted for age, sex, and height according to Indian derived regression equations. RESULTS: Respiratory symptoms were significantly more common and lung function (percentage predicted forced expiratory volume in one second (FEV1), forced vital capacity (FVC), forced expiratory flow between 25% and 75% of vital capacity (FEF25-75), and FEV1/FVC ratio) was reduced among those reporting exposure to the gas leak. The frequency of symptoms fell as exposure decreased (as estimated by distance lived from the plant), and lung function measurements displayed similar trends. These findings were not wholly accounted for by confounding by smoking or literacy, a measure of socioeconomic status. Lung function measurements were consistently lower in those reporting symptoms. CONCLUSION: Our results suggest that persistent small airways obstruction among survivors of the 1984 disaster may be attributed to gas exposure.
机译：目的：研究暴露于1984年博帕尔气体泄漏在持续性阻塞性气道疾病发展中的作用。设计：横断面调查。地点：印度博帕尔。受试者：从联合碳化物工厂的居住距离分层的454名成年人的随机样本。主要观察指标：自我报告的呼吸道症状。通过简单的肺活量测定法测量的肺功能指数，并根据印度衍生的回归方程对年龄，性别和身高进行调整。结果：呼吸系统症状更为常见，肺功能（百分比预测的一秒钟内的强制呼气量（FEV1），强制肺活量（FVC），肺活量的25％至75％（FEF25-75）之间以及FEV1 / FVC比值）在那些报告有气体泄漏暴露的人群中降低了。症状的发生率随着暴露量的减少而减少（通过与植物的生存距离进行估算），并且肺功能测量结果显示出相似的趋势。这些发现并不能完全由吸烟或识字（一种社会经济地位的衡量标准）混淆所造成。那些报告症状的肺功能测量值始终较低。结论：我们的结果表明，1984年灾难幸存者中持续的小气道阻塞可能归因于气体暴露。

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