Pharmacokinetics of enrofloxacin after intravenous and intramuscular administration in Angora goats.

机译：恩诺沙星在安哥拉山羊中静脉内和肌肉内给药后的药代动力学。

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Pharmacokinetics and bioavailability of enrofloxacin were determined after single intravenous (IV) and intramuscular (IM) administrations of 5 mg/kg body weight (BW) to 5 healthy adult Angora goats. Plasma enrofloxacin concentrations were measured by high performance liquid chromatography. Pharmacokinetics were best described by a 2-compartment open model. The elimination half-life and volume of distribution after IV and IM administrations were similar (t1/2beta, 4.0 to 4.7 h and Vd(ss),1.2 to 1.5 L/kg, respectively). Enrofloxacin was rapidly (t1/2a, 0.25 h) and almost completely absorbed (F, 90%) after IM administration. Mean plasma concentrations of enrofloxacin at 24 h after IV and IM administration (0.07 and 0.09 microg/mL, respectively) were higher than the minimal inhibitory concentration (MIC) values for most pathogens. In conclusion, once-daily IV and IM administration of enrofloxacin (5 mg/kg BW) in Angora goats may be useful in treatment of infectious diseases caused by sensitive pathogens.

机译：在对5只健康的成年安哥拉山羊进行5 mg / kg体重（BW）的单次静脉内（IV）和肌内（IM）施用后，确定了恩诺沙星的药代动力学和生物利用度。通过高效液相色谱法测定血浆恩诺沙星浓度。药代动力学最好用两室开放模型来描述。静脉注射和肌肉注射后的消除半衰期和分布体积相似（t1 / 2beta，4.0至4.7 h和Vd（ss），1.2至1.5 L / kg）。 IM给药后，恩诺沙星迅速（t1 / 2a，0.25小时）并几乎完全吸收（F，90％）。 IV和IM给药后24小时的恩诺沙星平均血浆浓度（分别为0.07和0.09 microg / mL）高于大多数病原体的最低抑菌浓度（MIC）值。总之，安哥拉山羊每天一次静脉内和即时施用恩诺沙星（5 mg / kg体重）可用于治疗由敏感病原体引起的传染病。

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期刊名称 Canadian Journal of Comparative Medicine
作者
M Elmas; B Tras; S Kaya; A L Bas; E Yazar; E Yarsan;
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年(卷),期 2001(65),1
年度 2001
页码 64–67
总页数 4
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1. Pharmacokinetics of enrofloxacin after intravenous and intramuscular administration in Angora goats. [J] . M Elmas, B Tras, S Kaya, Canadian Journal of Veterinary Research . 2001,第1期

机译：恩诺沙星在安哥拉山羊中静脉和肌肉内给药后的药代动力学。
2. Pharmacokinetics of enrofloxacin following intravenous and intramuscular administration in Angora rabbits. [J] . Elmas M, Uney K, Yazar E, Research in Veterinary Science . 2007,第2期

机译：在安哥拉兔中静脉和肌肉内给药后，恩诺沙星的药代动力学。
3. Pharmacokinetics of enrofloxacin and the rate of formation of its metabolite ciprofloxacin following intravenous and intramuscular single dose administration to male buffalo calves [J] . Sharma PK, Ahmad AH, Sharma LD, The Veterinary Journal . 2003,第1期

机译：对雄性水牛小牛进行静脉和肌肉单次给药后，恩诺沙星的药代动力学及其代谢产物环丙沙星的形成速率
4. Pharmacokinetics and Bioavailability of a Sulfadiazine/Trimethoprim Combination following Intravenous, Intramuscular, and Oral Administration in Ostriches (Struthio camelus) [C] . Tariq M. Hantash, Ehab A. Abu-Basha Annual Conference of the Association of Avian Veterinarians . 2008

机译：静脉注射，肌肉内和口服给药后磺胺嗪/三甲基氯化西瓜组合的药代动力学和生物利用度（Struthio Camelus）
5. A comparison of the intramuscular and intravenous routes for administration of meperidine to nulliparous and multiparous labouring women [D] . Mussell, Susan Marie. 2000

机译：向未产妇和多胎劳动妇女服用哌替啶的肌肉内和静脉内途径比较
6. Pharmacokinetics of enrofloxacin given by the oral intravenous and intramuscular routes in broiler chickens. [O] . K Bugyei, W D Black, S McEwen 1999

机译：通过口服静脉内和肌肉内途径在肉鸡中给予恩诺沙星的药代动力学。
7. Pharmacokinetic behavior and pharmacokinetic/pharmacodynamic indices of marbofloxacin after intravenous, subcutaneous, and intramuscular administrations in buffalo calves (<10days old) [O] . 2012

机译：在水牛犊中（<10天龄）静脉，皮下和肌肉内给药后，马尔福沙星的药代动力学行为和药代动力学/药效动力学指数

Pharmacokinetics of enrofloxacin after intravenous and intramuscular administration in Angora goats.

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