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Genomic analysis of porcine circovirus type-2 isolates in Alberta pigs demonstrating clinical porcine circovirus associated disease (PCVAD)

机译：猪圆环病毒2型分离株的基因组分析证明了临床猪圆环病毒相关疾病（PCVAD）

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Nineteen pigs with clinical signs of porcine circovirus associated diseases (PCVAD) on 5 Alberta pig farms were examined pathologically, including gross pathology, histopathology, and immunohistochemistry. Polymerase chain reaction (PCR) for porcine circovirus type-2 (PCV-2) and sequence analysis was performed on tissue samples of 12 animals. Results showed that new strains of porcine circovirus type-2 genogroup b were present in most pigs that were positive for PCV-2. Furthermore, a mixed infection with PCV-2a and PCV-2b occurred in the liver and lungs of 1 pig. Comparison of whole genome sequences representing known viruses and the newly discovered Alberta viruses revealed mutations distributed over the entire genome of PCV-2; however, sequences encoding for immunodominant epitopes of PCV-2 appear to be unaffected by these mutations.

机译：在5个艾伯塔省养猪场中对19头具有猪圆环病毒相关疾病（PCVAD）临床症状的猪进行了病理检查，包括总体病理学，组织病理学和免疫组织化学。猪圆环病毒2型（PCV-2）的聚合酶链反应（PCR）和序列分析在12只动物的组织样本上进行。结果表明，在大多数猪中都出现了新的猪圆环病毒2型基因组b株，它们对PCV-2呈阳性。此外，在1头猪的肝和肺中发生了PCV-2a和PCV-2b的混合感染。比较代表已知病毒和新发现的艾伯塔病毒的全基因组序列，发现突变遍布PCV-2的整个基因组。但是，编码PCV-2免疫优势表位的序列似乎不受这些突变的影响。

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期刊名称 Canadian Journal of Comparative Medicine
作者
Leila McIntyre; Mark Chaiyakul; Edward G. Clark; Frank Marshall; Markus Czub;
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年(卷),期 2010(74),2
年度 2010
页码 149–152
总页数 4
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1. Genomic analysis of porcine circovirus type-2 isolates in Alberta pigs demonstrating clinical porcine circovirus associated disease (PCVAD) [J] . Leila McIntyre, Mark Chaiyakul, Edward G. Clark, Canadian Journal of Veterinary Research . 2010,第2期

机译：阿尔伯塔猪中猪圆环病毒2型分离株的基因组分析，证明了临床猪圆环病毒相关疾病（PCVAD）
2. Genomic analysis of porcine circovirus type-2 isolates in Alberta pigsdemonstrating clinical porcine circovirus associated disease (PCVAD) [J] . Leila McIntyre, Mark Chaiyakul, Edward G. Clark, Canadian Journal of Veterinary Research . 2010,第2期

机译：猪圆环病毒2型分离株的基因组分析证明了猪圆环病毒临床相关疾病（PCVAD）
3. The effect of vaccination against Porcine reproductive and respiratory syndrome virus (PRRSV) on the Porcine circovirus-2 (PCV-2) load in porcine circovirus associated disease (PCVAD) affected pigs [J] . Genzow Marika, Schwartz Kent, Gonzalez Glenda, Canadian Journal of Veterinary Research . 2009,第2期

机译：猪繁殖与呼吸综合征病毒（PRRSV）疫苗接种对猪圆环病毒相关疾病（PCVAD）感染猪的猪圆环病毒2（PCV-2）负荷的影响
4. Contributing factors and their effects on growth rate and mortality in a herd clinically affected by porcine circovirus associated disease (PCVAD) [C] . John Greving, Derald Holtkamp Annual Meeting of the American Association of Swine Veterinarians . 2008

机译：患有猪循环系统病毒相关疾病（PCVAD）临床影响的植物中生长率和死亡率的贡献因素及其影响
5. Investigation into the control of porcine circovirus type 2 associated diseases (PCVAD). [D] . Ruiz Lopez, Jose Alberto. 2009

机译：猪圆环病毒2型相关疾病（PCVAD）的控制研究。
6. The effect of vaccination against Porcine reproductive and respiratory syndrome virus (PRRSV) on the Porcine circovirus-2 (PCV-2) load in porcine circovirus associated disease (PCVAD) affected pigs [O] . Marika Genzow, Kent Schwartz, Glenda Gonzalez, 2009

机译：猪繁殖与呼吸综合征病毒（PRRSV）疫苗接种对猪圆环病毒相关疾病（PCVAD）感染猪的猪圆环病毒2（PCV-2）负荷的影响
7. Three Cases of Nonsuppurative Meningoencephalitis with Multinucleated Giant Cells in Porcine Circovirus Associated Disease (PCVAD)-Affected Pigs [O] . Niho MURAYAMA, Toru KUSUHARA, Kazumaro INO, 2014

机译：猪循环系统病毒相关疾病中多核巨细胞的三种非植物脑膜炎病例（PCVAD）

Genomic analysis of porcine circovirus type-2 isolates in Alberta pigs demonstrating clinical porcine circovirus associated disease (PCVAD)

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