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首页> 美国卫生研究院文献>Cardiovascular Diseases >Non-Gadolinium-Enhanced 3-Dimensional Magnetic Resonance Angiography for the Evaluation of Thoracic Aortic Disease
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Non-Gadolinium-Enhanced 3-Dimensional Magnetic Resonance Angiography for the Evaluation of Thoracic Aortic Disease

机译：非-增强三维磁共振血管成像技术评估胸主动脉疾病

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We compared image quality and diagnostic accuracy of a noncontrast 3-dimensional magnetic resonance angiography (NC-MRA) technique (balanced steady-state free-precession sequence) to contrast-enhanced MRA (CE-MRA) for evaluation of thoracic aortic disease.The CE-MRA provides 3-dimensional high-resolution images of the thoracic aorta that are important in the evaluation of patients with aortic disease. However, recent concerns with the potential nephrotoxic effects of gadolinium contrast medium limit the application of CE-MRA for patients who have significant renal insufficiency.Twenty-one patients (mean age, 51 yr; 18 men) who underwent NC-MRA and CE-MRA for evaluation of thoracic aortic disease were retrospectively identified. Data sets were reviewed by 2 readers who were blinded to the patients' information. The thoracic aorta was divided into 5 segments. Image quality and reader confidence for diagnosis of aortic pathology were rated on 5-point scales. The Wilcoxon matched-pairs signed rank test and the Student t test were used for comparisons.The NC-MRA identified all pathologic findings with 100% diagnostic accuracy and similar reader confidence, when compared with CE-MRA. Although overall image quality was not significantly different, superior image quality was observed at the aortic root (4.4 ± 0.8 vs 3.2 ± 0.9, P <0.0005) and ascending aorta (4.1 ± 1 vs 3.7 ± 0.9, P=0.05) respectively.In conclusion, NC-MRA is a useful alternative for evaluation and follow-up of thoracic aortic disease, especially for patients with poor intravenous access or contraindications to gadolinium use.
机译：我们将无对比度3维磁共振血管造影（NC-MRA）技术（平衡稳态自由进动序列）与对比增强MRA（CE-MRA）的图像质量和诊断准确性进行了比较，以评估胸主动脉疾病。 CE-MRA提供了胸主动脉的3维高分辨率图像，这在评估主动脉疾病患者中很重要。但是，最近对of造影剂潜在的肾毒性作用的关注限制了CE-MRA在严重肾功能不全患者中的应用.21名患者（平均年龄51岁; 18名男性）接受了NC-MRA和CE-回顾性鉴定了用于评估胸主动脉疾病的MRA。数据集由2位对患者信息不了解的读者进行了审查。胸主动脉分为5段。图像质量和读者对主动脉病理诊断的置信度按5分制评分。比较使用Wilcoxon配对配对符号秩检验和St​​udent t检验。与CE-MRA相比，NC-MRA以100％的诊断准确性和相似的读者置信度鉴定了所有病理结果。尽管总体图像质量没有显着差异，但在主动脉根部（4.4±0.8 vs 3.2±0.9，P <0.0005）和升主动脉（4.1±1 vs 3.7±0.9，P = 0.05）分别观察到较高的图像质量。结论是，NC-MRA是评估和随访胸主动脉疾病的有用替代方法，特别是对于静脉内通路不良或使用ado禁忌症的患者。

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