首页> 美国卫生研究院文献>Clinical and Developmental Immunology >Association between B Cell Growth Factors and Primary Sjögrens Syndrome-Related Autoantibodies in Patients with Non-Hodgkins Lymphoma

【2h】

Association between B Cell Growth Factors and Primary Sjögrens Syndrome-Related Autoantibodies in Patients with Non-Hodgkins Lymphoma

机译：非霍奇金淋巴瘤患者中B细胞生长因子与原发性Sjögren综合征相关自身抗体之间的关联

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

Despite the overall success of using R-CHOP for the care for non-Hodgkin's lymphoma patients, it is clear that the disease is quite complex and new insight is needed to further stratify the patient for a better personized treatment. In current study, based on previous studies from animal model, new panels combining well-established cytokine (BAFF) and autoantibodies (anti-SSA/Ro) with newly identified cytokine (IL14) and autoantibodies (TSA) were used to evaluate the association between B cell growth factor and Sjögren's related autoantibodies in NHL patients. The result clearly indicates that there was a unique difference between BAFF and IL14 in association with autoantibodies. While serum BAFF was negatively associated with the presence of both traditional anti-SSA/Ro and novel TSA antibodies in GI lymphoma patient, IL14 was positively associated with the presence of both traditional anti-SSA/Ro and novel TSA antibodies in non-GI lymphoma patient. Long-term follow-ups on these patients and evaluation of their response to the R-CHOP treatment and recurrence rate will be very interesting. Our result provides a solid evidence to support using novel diagnostic panel to better stratify the NHL patients.

机译：尽管使用R-CHOP治疗非霍奇金淋巴瘤患者取得了总体成功，但很明显，该疾病非常复杂，需要新的见识以进一步对患者进行分层以进行更好的个性化治疗。在当前的研究中，基于对动物模型的先前研究，使用新建立的结合成熟细胞因子（BAFF）和自身抗体（anti-SSA / Ro）与新近鉴定的细胞因子（IL14）和自身抗体（TSA）的组合来评估NHL患者的B细胞生长因子和Sjögren相关的自身抗体。结果清楚地表明，BAFF和IL14与自身抗体之间存在独特的区别。虽然GI淋巴瘤患者血清BAFF与传统抗SSA / Ro和新型TSA抗体均呈负相关，但IL14与非GI淋巴瘤与传统抗SSA / Ro和新型TSA抗体均呈正相关患者。对这些患者进行长期随访并评估他们对R-CHOP治疗的反应和复发率将非常有趣。我们的结果提供了坚实的证据来支持使用新型诊断专家组更好地对NHL患者进行分层。

著录项

期刊名称 Clinical and Developmental Immunology
作者
Zhenhua Xian; Dehua Fu; Shuang Liu; Yang Yao; Chun Gao;
展开▼
作者单位

展开▼
年(卷),期 2019(2019),-1
年度 2019
页码 7627384
总页数 7
原文格式 PDF
正文语种
中图分类免疫学;
关键词

相似文献

外文文献
中文文献
专利

1. Association between B Cell Growth Factors and Primary Sj?gren’s Syndrome-Related Autoantibodies in Patients with Non-Hodgkin’s Lymphoma [J] . Zhenhua Xian, Dehua Fu, Shuang Liu, Journal of immunology research. . 2019,第1期

机译：B细胞生长因子和原发性SJ之间的关联与非霍奇金淋巴瘤患者的综合征相关的自身抗体
2. The relationship between the presence of autoantibodies, indicators of local and systemic inflammation, the serum concentration of B-cell activating factor (BAFF) and the intensity of salivary gland infiltration in patients with primary Sj?gren’s syndrome – a preliminary study [J] . Maria Ma?lińska, Ewa Kontny, Brygida Kwiatkowska Reumatologia . 2015,第6期

机译：自身抗体的存在，局部和全身炎症指标，B细胞激活因子（BAFF）的血清浓度与原发性干燥综合征患者唾液腺浸润强度之间的关系–初步研究
3. An in silico Approach Reveals Associations between Genetic and Epigenetic Factors within Regulatory Elements in B Cells from Primary Sj?gren’s Syndrome Patients [J] . Orsia D. Konsta, Christelle Le Dantec, Amandine Charras, Frontiers in Immunology . 2015,第2期

机译：一种 in silico 方法揭示了原发性干燥综合征患者B细胞调节元件内遗传因素和表观遗传因素之间的关联
4. Predicting lymphoma outcomes and risk factors in patients with primary Sjögren’s Syndrome using gradient boosting tree ensembles [C] . Vasileios C. Pezoulas, Themis P. Exarchos, Athanasios G. Tzioufas, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

机译：使用梯度增强树组合预测原发性干燥综合征患者的淋巴瘤结局和危险因素
5. Immunopathogenic Mechanisms in Primary Sj?gren’s Syndrome [D] . Bj?rk, Albin. 2021

机译：原发性SJ的免疫致病机制？GREN的综合征
6. The relationship between the presence of autoantibodies indicators of local and systemic inflammation the serum concentration of B-cell activating factor (BAFF) and the intensity of salivary gland infiltration in patients with primary Sjögrens syndrome – a preliminary study [O] . Maria Maślińska, Ewa Kontny, Brygida Kwiatkowska 2015

机译：原发性干燥综合征患者自身抗体的存在局部和全身炎症指标B细胞活化因子血清浓度和唾液腺浸润强度之间的关系–初步研究
7. The relationship between the presence of autoantibodies, indicators of local and systemic inflammation, the serum concentration of B-cell activating factor (BAFF) and the intensity of salivary gland infiltration in patients with primary Sjögren’s syndrome – a preliminary study [O] . Maria Maślińska, Ewa Kontny, Brygida Kwiatkowska 2016

机译：原发性干燥综合征患者自身抗体存在，局部和全身炎症指标，B细胞活化因子（BaFF）血清浓度与唾液腺浸润强度的关系 - 初步研究

Association between B Cell Growth Factors and Primary Sjögrens Syndrome-Related Autoantibodies in Patients with Non-Hodgkins Lymphoma

摘要

著录项

相似文献

相关主题

期刊订阅