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首页> 美国卫生研究院文献>Clinical and Diagnostic Laboratory Immunology >Relationship between Serum Bactericidal Activity and Serogroup-Specific Immunoglobulin G Concentration for Adults Toddlers and Infants Immunized with Neisseria meningitidis Serogroup C Vaccines
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Relationship between Serum Bactericidal Activity and Serogroup-Specific Immunoglobulin G Concentration for Adults Toddlers and Infants Immunized with Neisseria meningitidis Serogroup C Vaccines

机译：成人幼儿和脑膜炎奈瑟菌血清群C疫苗免疫的婴儿血清杀菌活性与血清群特异性免疫球蛋白G浓度之间的关系

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A new meningococcal group C-CRM197 conjugate vaccine (MnCC; Meningitec) has been evaluated in multiple clinical trials in the United States and most recently has been approved for routine administration in the United Kingdom. Meningococcal serogroup C (MnC)-specific immunoglobulin G (IgG) antibodies in pre- and postimmunization sera obtained from healthy U.S. adults, toddlers, and infants were quantitated by enzyme-linked immunosorbent assay (ELISA) and by an antibody-dependent, complement-mediated serum bactericidal assay (SBA). Serogroup-specific IgG antibody (micrograms per milliliter) in adults immunized either with the quadrivalent polysaccharide (A, C, Y, and W-135) vaccine or with MnCC showed a strong correlation (r = 0.848 and 0.934, respectively) by linear regression analysis with SBA. Sera from infants immunized with the MnCC (n = 30) and an age-matched unimmunized control group (n = 15) were also analyzed. Linear regression analysis of serum bactericidal and IgG ELISA data from sera obtained at 2 months of age (preimmunization) showed no correlation; however, a high degree of correlation was observed at time points after two (r = 0.877) and three (r = 0.951) immunizations, where significant rises in anti-MnC polysaccharide antibodies occurred relative to the age-matched control group. Infants previously primed with 3 doses of MnCC were given a booster dose of conjugate vaccine at 12 to 15 months of age. The correlation coefficient of ELISA to SBA for combined pre- and postbooster data was r = 0.836 (n = 48 pairs). In conclusion, increases in serum bactericidal activity in immunized adult, toddler, and infant populations were found to correlate very well with increases in serogroup-specific IgG concentrations, whereas the correlation between these two assays in nonimmunized 2-month-old infants was poor. Characterizing the relationship between these methods is important for understanding the significance of antigen-specific antibody concentrations relative to vaccine performance and protection from disease.
机译：一种新的脑膜炎球菌C-CRM197共轭疫苗（MnCC; Meningitec）已在美国进行了多项临床试验评估，最近已在英国批准用于常规给药。通过酶联免疫吸附测定（ELISA）和抗体依赖性补体-免疫球蛋白定量分析从健康的美国成年人，学步儿童和婴儿获得的免疫前和免疫后血清中的脑膜炎球菌C群（MnC）特异性免疫球蛋白G（IgG）抗体。介导的血清杀菌测定（SBA）。通过线性回归免疫接种四价多糖（A，C，Y和W-135）或MnCC的成年人的血清群特异性IgG抗体（每毫升微克）显示出很强的相关性（分别为r = 0.848和0.934）用SBA分析。还分析了用MnCC免疫的婴儿（n = 30）和年龄匹配的未免疫对照组（n = 15）的血清。 2个月龄（免疫前）血清血清杀菌和IgG ELISA数据的线性回归分析没有相关性；但是，在两次（r = 0.877）和三次（r = 0.951）免疫接种后的时间点观察到高度相关性，相对于年龄匹配的对照组，抗MnC多糖抗体明显升高。先前用3剂MnCC初免的婴儿在12至15个月大时接受了加强剂量的结合疫苗。合并后的booster数据，ELISA与SBA的相关系数为r = 0.836（n = 48对）。总之，发现在免疫的成人，幼儿和婴儿人群中血清杀菌活性的增加与血清群特异性IgG浓度的增加非常相关，而在未免疫的2个月大婴儿中，这两种检测之间的相关性很差。表征这些方法之间的关系对于理解抗原特异性抗体浓度相对于疫苗性能和预防疾病的重要性非常重要。

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