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首页> 外国专利> Vaccine composition, processes for immunization against neisseria gonorrhoeae and to prepare a vaccine composition, isolated and purified DNA sequence, plasmid, host cell, process for producing a chimeric recombinant pilin protein from neisseria gonorrhoeae and neisseria meningitidis, chimeric recombinant protein isolated and purified from neisseria gonorhoeae and neisseria meningitidis, and, process for immunization against neisseria muningitidis

Vaccine composition, processes for immunization against neisseria gonorrhoeae and to prepare a vaccine composition, isolated and purified DNA sequence, plasmid, host cell, process for producing a chimeric recombinant pilin protein from neisseria gonorrhoeae and neisseria meningitidis, chimeric recombinant protein isolated and purified from neisseria gonorhoeae and neisseria meningitidis, and, process for immunization against neisseria muningitidis

机译：疫苗组合物，针对淋病奈瑟氏球菌的免疫方法以及制备疫苗组合物，分离和纯化的DNA序列，质粒，宿主细胞，从淋病奈瑟氏球菌和脑膜炎奈瑟氏球菌生产嵌合重组菌毛蛋白的方法，从奈瑟氏球菌分离和纯化的嵌合重组蛋白淋病奈瑟菌和脑膜炎奈瑟氏球菌，以及针对慕尼黑菌的免疫接种方法

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"VACCINE COMPOSITION, PROCESSES FOR IMMUNIZATION AGAINST NEISSERIA GONORRHOEAE AND TO PREPARE A VACCINE COMPOSITION, ISOLATED AND PURIFIED DNA SEQUENCE, PLASMID, HOSEPIN CELL, PROCEDURE OF NEITHER PROTEIN PROTEIN. ISOLATED AND PURIFIED CHEMISTRY OF NEISSERIA GONORRHOEAE AND NEISSERIA MENINGITIDIS, E, PROCESS FOR IMMUNIZATION AGAINST NEISSERIA MENINGITIDIS "The pile genes of each of the Neisseria gonorrhoeae and Neisseria meningitidis are cloned and their corresponding recombinant protein proteins. In addition, a chimeric pilE gene is constructed in which the Neisseria meningitidis Class I pilE gene region encoding the amino terminal region of the pilin protein is replaced by the corresponding Neisseria gonorrhoeae pilE gene region. The recombinant meningococcal chimeric class I pilin protein is expressed at higher levels than the pilin protein expressed by the full-length pilE gene of Neisseria meningitidis. In addition, a chimeric pilE gene is constructed in which the region of the Neisseria meningitidis class II pilE gene encoding the carboxy terminal region of the pilin protein is replaced by the corresponding region of the Neisseria gonorrhoeae pilE gene. Recombinant pilin proteins are used in vaccines to protect against disease caused by Neisseria gonorrhoeae or Neisseria meningitidis.
机译：“疫苗的组成，针对淋病奈瑟氏球菌的免疫接种过程，以及制备疫苗的组成，分离和纯化的DNA序列，质粒，胶体细胞，新蛋白的过程，分离和纯净的肠炎，其抗原性对抗淋病奈瑟氏菌“克隆了淋病奈瑟氏球菌和脑膜炎奈瑟氏球菌的堆基因，并克隆了它们各自的重组蛋白。另外，构建嵌合pilE基因，其中编码菌毛蛋白的氨基末端区域的脑膜炎奈瑟氏球菌I类pilE基因区域被相应的淋病奈瑟氏球菌pilE基因区域代替。重组脑膜炎球菌嵌合I类菌毛蛋白的表达水平高于脑膜炎奈瑟氏球菌全长pilE基因表达的菌毛蛋白。另外，构建嵌合pilE基因，其中编码菌毛蛋白的羧基末端区域的脑膜炎奈瑟氏球菌II类pilE基因的区域被淋病奈瑟氏菌pilE基因的相应区域代替。重组菌毛蛋白可用于疫苗中，以预防淋病奈瑟氏球菌或脑膜炎奈瑟氏球菌引起的疾病。

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