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首页> 美国卫生研究院文献>Clinical Medicine. Cardiology >Bedside–to-Bench Translational Research for Chronic Heart Failure: Creating an Agenda for Clients Who Do Not Meet Trial Enrollment Criteria
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Bedside–to-Bench Translational Research for Chronic Heart Failure: Creating an Agenda for Clients Who Do Not Meet Trial Enrollment Criteria

机译：慢性心力衰竭的从床到床的转化研究：为不符合试验入组标准的客户创建议程

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摘要

Congestive heart failure (CHF) is a chronic condition usually without cure. Significant developments, particularly those addressing pathophysiology, mainly started at the bench. This approach has seen many clinical observations initially explored at the bench, subsequently being trialed at the bedside, and eventually translated into clinical practice. This evidence, however, has several limitations, importantly the generalizability or external validity. We now acknowledge that clinical management of CHF is more complicated than merely translating bench-to-bedside evidence in a linear fashion. This review aims to help explore this evolving area from an Australian perspective. We describe the continuation of research once core evidence is established and describe how clinician–scientist collaboration with a bedside-to-bench view can help enhance evidence translation and generalizability. We describe why an extension of the available evidence or generating new evidence is occasionally needed to address the increasingly diverse cohort of patients. Finally, we explore some of the tools used by basic scientists and clinicians to develop evidence and describe the ones we feel may be most beneficial.
机译：充血性心力衰竭（CHF）是一种慢性疾病，通常无法治愈。重大进展，特别是那些涉及病理生理学的进展，主要是从实验台开始的。这种方法已经看到了许多临床观察结果，这些观察结果最初是在实验台上进行探索的，随后在床边进行了试验，最终转化为临床实践。但是，该证据有几个局限性，重要的是普遍性或外部有效性。我们现在认识到，CHF的临床管理比仅仅线性地转换替补证据更为复杂。这篇综述旨在从澳大利亚的角度帮助探索这一不断发展的领域。我们描述了一旦建立了核心证据，就说明了研究的继续，并描述了从临床到临床的临床医生与科学家之间的合作如何有助于增强证据的翻译和推广性。我们描述了为什么有时需要扩展现有证据或产生新证据来解决日益多样化的患者群体。最后，我们探索了基础科学家和临床医生用来开发证据的一些工具，并描述了我们认为最有益的工具。

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