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首页> 美国卫生研究院文献>Clinical Molecular Pathology >A fatal case of disseminated aspergillosis caused by a non-sporulating strain of Aspergillus fumigatus
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A fatal case of disseminated aspergillosis caused by a non-sporulating strain of Aspergillus fumigatus

机译：由非孢子型烟曲霉引起的传播性曲霉病的致命病例

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This report describes the case of a 38 year old pregnant woman with fatal disseminated aspergillosis and multiorgan failure, which was preceded by a long history of allergic bronchopulmonary aspergillosis. Postmortem revealed massive infarction and abscess formation in both lungs. Histology revealed a focal granulomatous response. Fungal infiltration with areas of necrosis were also seen in the liver, spleen, and paratracheal, mediastinal, para-aortic, and hilar lymph nodes. Culture of tissue samples produced a non-sporulating, beige coloured fungus that developed green pigmentation only after three weeks of incubation. Nucleotide sequencing of the D1–D2 region of the large ribosomal subunit revealed 100% homology with Aspergillus fumigatus. Minimum inhibitory concentrations for amphotericin B and itraconazole were both 0.25 mg/litre (susceptible). Further work is urgently required to determine the prevalence of such non-sporulating strains and their relevance to clinical infection.
机译：该报告描述了一名38岁孕妇的致命性弥散性曲霉病和多器官功能衰竭的病例，此例之前有过敏性支气管肺曲霉病的悠久历史。死后检查显示两个肺都有大量梗塞和脓肿形成。组织学显示局灶性肉芽肿反应。在肝脏，脾脏和气管旁，纵隔，主动脉旁和肺门淋巴结中也可见到具有坏死区域的真菌浸润。组织样品的培养产生了非孢子形成的米色真菌，仅在孵育三周后才出现绿色色素沉着。大核糖体亚基的D1-D2区的核苷酸测序显示与烟曲霉100％同源。两性霉素B和伊曲康唑的最低抑菌浓度均为0.25 mg / L（易感）。迫切需要进一步的工作来确定这种非产孢菌株的流行及其与临床感染的相关性。

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