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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Reduced Recovery of Depression in Female T Allele Carriers of TNF-RII rs1061622 at Earlier Stage after Wenchuan Earthquake
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Reduced Recovery of Depression in Female T Allele Carriers of TNF-RII rs1061622 at Earlier Stage after Wenchuan Earthquake

机译：汶川地震后早期TNF-RII rs1061622的女性T等位基因携带者的抑郁恢复降低

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Objective: The aim of current study was to explore longitudinally the prevalence, severity, potential factors, and predictors of depression among Chinese Han adolescent survivors with different genotypes of tumor necrosis factor receptor-II (TNF-RII) rs1061622 after the 2008 Wenchuan earthquake. Method: TNF-RII rs1061622 variants were examined by polymerase chain reaction–restriction fragment length polymorphism and verified by DNA sequencing. Depression symptoms were assessed by Beck Depression Inventory (BDI) among 439 high school students at 6, 12, and 18 months after the earthquake. Results: No significant differences were observed in depression prevalence and BDI scores between the TT homozygotes and the G allele carriers in both the male and female subjects. However, the female TT homozygotes had a higher depression prevalence than the male TT homozygotes at 6, 12, and 18 months, whereas the female G allele carriers had a higher depression prevalence than the male G allele carriers only at 6 and 12 months after the earthquake. Moreover, BDI scores declined in the male subjects with both genotypes and only in the female G allele carriers at 12 months when compared with those at 6 months. Furthermore, the predictors of depression severity or potential factors of depression prevalence were different between the G allele carriers and the TT homozygotes at different times after the earthquake. Conclusion: It is concluded that the association of TNF-RII rs1061622 with depression is longitudinally different in Chinese Han adolescents after the 2008 Wenchuan earthquake. The T allele may be associated with reduced recovery of depression in female adolescents in the earlier stage of depression rehabilitation.
机译：目的：本研究的目的是纵向探讨2008年汶川地震后不同基因型肿瘤坏死因子受体II（TNF-RII）rs1061622的中国汉族青少年幸存者的患病率，严重程度，潜在因素以及抑郁症的预测因素。方法：通过聚合酶链反应-限制性片段长度多态性检查TNF-RII rs1061622变异体，并通过DNA测序进行验证。地震后6、12和18个月，通过439例高中生的贝克抑郁量表（BDI）对抑郁症状进行了评估。结果：在男性和女性受试者中，TT纯合子和G等位基因携带者之间的抑郁患病率和BDI得分均无显着差异。然而，雌性TT纯合子的抑郁发生率比雄性TT纯合子在6、12和18个月时高，而雌性G等位基因携带者在雄性G等位基因携带者后6个月和12个月才具有更高的抑郁发生率。地震。此外，与6个月时相比，两种基因型的男性受试者中的BDI得分均下降，仅女性G等位基因携带者中的BDI得分下降。此外，在地震后的不同时间，G等位基因携带者和TT纯合子之间抑郁严重程度的预测因子或抑郁流行的潜在因素是不同的。结论：结论是，2008年汶川地震后，中国汉族青少年TNF-RII rs1061622与抑郁症的关联在纵向上是不同的。 T等位基因可能与抑郁症康复初期女性青春期抑郁症的恢复减少有关。

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