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首页> 外文期刊>International journal of psychiatry in clinical practice >D allele of insertion/deletion polymorphism at angiotensin-converting enzyme gene is associated with reduced prevalence and severity of depression among Chinese adolescents at early stage after Wenchuan earthquake
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D allele of insertion/deletion polymorphism at angiotensin-converting enzyme gene is associated with reduced prevalence and severity of depression among Chinese adolescents at early stage after Wenchuan earthquake

机译：血管紧张素转换酶基因的插入/缺失多态性等位基因与汶川地震发生后早期中国青少年抑郁症的患病率降低和严重程度有关

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摘要

Objective: The purpose of the present study was to longitudinally investigate the association of insertion/deletion (I/D) polymorphism at angiotensin-converting enzyme gene (ACE) with depression in Chinese adolescents experiencing the 2008 Wenchuan earthquake.Methods: Variants of ACE I/D were identified by polymerase chain reaction and verified by DNA sequencing. Depression symptoms were assessed by the Beck Depression Inventory (BDI) among high school students at 6, 12 and 18 months after the earthquake.Results: The D-allele carriers had lower depression prevalence than II homozygotes at 6, 12 and 18 months after the earthquake only in females, but not in males. Meanwhile, BDI scores were reduced in the female D-allele carriers when compared with those in the female II homozygotes at 6 and12 months after the earthquake. In addition, ACE I/D was found to be the predictors of BDI scores and depression prevalence at 6 and 12 months after the earthquake.Conclusions: These results suggest that the association of ACE I/D with depression are longitudinally different in Chinese Han adolescents after the 2008 Wenchuan earthquake. The D allele may be associated with reduced depression prevalence and severity in female adolescents in the early stage of depression rehabilitation during the follow-up.
机译：目的：本研究的目的是纵向研究插入/缺失（I / D）多态性在血管紧张素转换酶基因（ACE）的抑制作用2008年汶川地震的抑郁症。艾西州的患者：ACE I的变种通过聚合酶链反应鉴定/ D并通过DNA测序验证。在地震后6,12和18个月的高中生贝克抑郁症库存（BDI）评估了抑郁症状。结果：D-Allele携带者在6,12和18个月后的抑郁症比II纯合蛋白较低地震仅在女性中，但不在男性中。同时，与地震后6岁和12个月的雌性II纯合蛋白的那些相比，BDI分数减少了雌性D-等位基因载体。此外，发现ACE I / D是地震后6和12个月的BDI评分和抑郁症的预测因子。结论：这些结果表明，在中国汉族青少年的ACE I / D与抑郁症的关联是纵向不同的在2008年汶川地震之后。在随访期间，D等位基因可能与抑郁症康复早期的雌性青少年的抑郁症患病率和严重程度有关。

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