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Smelting Remains a Public Health Risk Nearly a Century Later: A Case Study in Pueblo Colorado USA

机译:近一个世纪后冶炼仍是公共卫生风险:美国科罗拉多州普韦布洛的案例研究

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摘要

Pueblo, Colorado has a long history of smelting activities, and recent studies raised concerns about lead exposure. This study tested 240 children in Pueblo for blood lead levels (BLLs) and found a significant association between distance from old smelters and children BLLs. Around 7.5% of Pueblo children had BLLs above the Centers for Disease Control and Prevention reference level of 5 µg/dL for elevated BLL, and 18.3% had BLLs between 3.3–4.9 µg/dL. Out of the 36 children who lived near former smelters, 13.9% had BLLs above 5 µg/dL vs. 6.37% for children living away from old smelters. The proportion of Pueblo children with elevated BLL was nearly three times the 2007–2010 United States national average (7.5% vs. 2.6%), and this was higher in the immediate vicinity of old smelters (13.9% vs. 2.6%). Genetic polymorphisms for ALAD-1 or ALAD-2 alleles, which play a role in susceptibility to lead toxicity, were not associated with children BBLs. Around 38.5% of houses sampled near the smelters had topsoil lead levels higher than the Environmental Protection Agency’s benchmark of 400 mg/kg. Our study resulted in the addition of areas of Pueblo to the EPA Superfund National Priorities List in December 2014, and cleanup is currently underway to minimize the public health risks.
机译:科罗拉多州普韦布洛(Pueblo)的冶炼活动历史悠久,最近的研究引起了人们对铅暴露的担忧。这项研究测试了普韦布洛的240名儿童的血铅水平(BLL),发现距老冶炼厂的距离与儿童BLL之间存在显着相关性。大约7.5%的Pueblo儿童的BLL高于疾病控制和预防中心的BLL升高参考水平5 µg / dL,而18.3%的BLL在3.3–4.9 µg / dL之间。在居住在原冶炼厂附近的36名儿童中,有13.9%的BLL高于5 µg / dL,而远离旧冶炼厂的儿童为6.37%。 Bue升高的普韦布洛儿童比例几乎是2007-2010年美国全国平均水平的三倍(7.5%比2.6%),而在老冶炼厂附近则更高(13.9%比2.6%)。 ALAD-1或ALAD-2等位基因的遗传多态性与铅毒性易感性有关,与儿童BBL无关。在冶炼厂附近采样的房屋中,约有38.5%的表层土壤铅含量高于美国环境保护局的400 mg / kg基准。我们的研究结果是在2014年12月将Pueblo区域添加到了EPA Superfund国家优先事项列表中,并且目前正在进行清理以最大程度地减少公共健康风险。

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