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首页> 美国卫生研究院文献>International Journal of Analytical Chemistry >Multianalytical Method Validation for Qualitative and Quantitative Analysis of Solvents of Abuse in Oral Fluid by HS-GC/MS
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Multianalytical Method Validation for Qualitative and Quantitative Analysis of Solvents of Abuse in Oral Fluid by HS-GC/MS

机译：HS-GC / MS定性和定量分析口服液中滥用溶剂的多分析方法验证

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摘要

The use of oral fluid as a biological matrix to monitor the use of drugs of abuse is a global trend because it presents several advantages and good correlation to the blood level. Thus, the present work aimed to develop and validate an analytical method for quantification and detection of solvents used as inhalants of abuse in oral fluid (OF), using Quantisal™ as collector device by headspace and gas chromatography coupled with a mass detector (HS-GC/MS). Chromatographic separation was performed with a ZB-BAC1 column and the total time of analysis was 11.8 min. The method showed good linearity (correlation coefficient higher than 0.99 for all solvents). The limits of detection ranged from 0.05 to 5 mg/L, while the lower limits of quantification ranged from 2.5 to 12.5 mg/L. Accuracy, precision, matrix effect, and residual effect presented satisfactory results, meeting the criteria accepted for the validation of bioanalytical methods. The method showed good selectivity considering that, for solvents coeluting at the same retention time, resolution was performed by the mass detector. The method developed proved to be adequate when applied in OF samples from users of drugs and may be used to monitor the abuse of inhalants in routine forensic analyses.
机译：使用口服液作为监测滥用药物的生物基质是一种全球趋势，因为它具有多种优势，并且与血液水平具有良好的相关性。因此，本工作旨在开发和验证一种分析方法，用于量化和检测用作口服液（OF）中滥用吸入剂的溶剂，该方法采用Quantisal™作为顶空收集器装置，并通过气相色谱与质量检测器（HS- GC / MS）。用ZB-BAC1色谱柱进行色谱分离，总分析时间为11.8分钟。该方法显示出良好的线性（所有溶剂的相关系数均高于0.99）。检出限为0.05至5μmg/ L，定量下限为2.5至12.5μmg/ L。准确度，精密度，基质效应和残留效应均显示出令人满意的结果，符合公认的生物分析方法验证标准。考虑到对于在相同保留时间共洗脱的溶剂，通过质量检测器进行分离，该方法显示出良好的选择性。当将这种方法应用于吸毒者的OF样品时，已证明是足够的，并且可以用于监测常规法医分析中吸入剂的滥用。

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