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Effects of modified electroconvulsive therapy on the cognitive function and blood parameters in female patients with schizophrenia

机译:改良电惊厥疗法对女性精神分裂症患者认知功能和血液参数的影响

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摘要

Background: This study aimed to investigate the effects of modified electroconvulsive therapy (MECT) on cognitive function and blood parameters in female patients with schizophrenia. Materials and methods: Female patients with schizophrenia (n = 23) received MECT while maintaining antipsychotic therapy. 1) White blood cell (WBC), alanine aminotransferase (ALT), creatine kinase (CK) and creatine kinase MB (CKMB) were measured at 10 min before and after MECT. 2) The severity of symptoms was evaluated before and after MECT by using the Positive and Negative Symptoms Scale (PANSS) and then the therapeutic effects of MECT were assessed. 3) Single nerve psychology test was used to assess the cognitive function. Results: 1) There were no significant differences in WBC, ALT, CK and CKMB before and after MECT (P > 0.05). 2) WBC, ALT and CKMB remained stable at different time points after MECT treatment (P > 0.05). But CK had statistical differences at different times before or after MECT treatment (P < 0.05). CK decreased since the first MECT and thereafter increased after the 7th treatment (P < 0.05). 3) The total score of PANSS decreased significantly after MECT (P < 0.05). 4) Digit span test showed no statistically significant differences in different time points (P > 0.05); Digital sign test and verbal fluency test showed significant differences in different times (P < 0.05). Conclusion: The CK figure decreased from the first to sixth MECT treatment and increased in the 7th MECT treatment, and the CKMB also increased in the 7th treatment. MECT treatment had significant effects on female patients with schizophrenia and could obviously improve patient’s cognitive function.
机译:背景:本研究旨在探讨改良的电惊厥疗法(MECT)对女性精神分裂症患者认知功能和血液参数的影响。材料和方法:精神分裂症女性患者(n = 23)在接受抗精神病药物治疗的同时接受了MECT治疗。 1)在MECT之前和之后的10分钟测量白细胞(WBC),丙氨酸转氨酶(ALT),肌酸激酶(CK)和肌酸激酶MB(CKMB)。 2)使用阳性和阴性症状量表(PANSS)评估MECT前后的症状严重程度,然后评估MECT的治疗效果。 3)采用单神经心理学测验评估其认知功能。结果:1)MECT前后WBC,ALT,CK和CKMB差异均无统计学意义(P> 0.05)。 2)MECT治疗后不同时间点白细胞,ALT和CKMB均保持稳定(P> 0.05)。但CK在MECT治疗前后不同时间有统计学差异(P <0.05)。自第一次MECT以来CK下降,而在第7次治疗后CK增加(P <0.05)。 3)MECT后PANSS总分明显降低(P <0.05)。 4)数字跨度测试显示不同时间点无统计学差异(P> 0.05);数字符号测试和口语流利度测试在不同时间显示出显着差异(P <0.05)。结论:从第一个到第六个MECT治疗,CK值下降,在第7个MECT治疗中增加,而在第7个治疗中CKMB也增加。 MECT治疗对女性精神分裂症患者有显着疗效,并且可以明显改善患者的认知功能。

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