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首页> 美国卫生研究院文献>International Journal of Clinical and Experimental Medicine >Impact of Xuebijing and ulinastatin as assistance for hemoperfusion in treating acute paraquat poisoning
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Impact of Xuebijing and ulinastatin as assistance for hemoperfusion in treating acute paraquat poisoning

机译：血必净和乌司他丁辅助血液灌流治疗急性百草枯中毒的作用

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Objective: As the effect of Xuebijing as combined treatment in hemoperfusion (HP) toward acute paraquat (PQ) poisoning is not clear. We retrospectively analyzed 119 cases of acute paraquat poisoning in Tianjin first central hospital; the patients were divided into 3 groups based on treatment. Control (group A) patients underwent standard hemoperfusion with conventional treatment, while the experimental groups combined hemoperfusion with Xuebijing (group B) or ulinastatin (group C). Standard biomedical indicators, such as organ dysfunction and mortality were recorded and compiled, both in short (<7 days) and long (7-28 days) terms. Then, the effect of Xuebijing in combination to the standard (HP) treatment was evaluated by direct comparison. The results showed that using either Xuebijing or ulinastatin as additional treatment to standard HP significantly helped the overall outcomes, as evidenced by lower organ dysfunction and mortality. In addition, Xuebijing (group B) yielded a more pronounced improvement compared with ulinastatin (group C) in combination with HP (All P<0.05). Our findings indicated that both Xuebijing and ulinastatin provided positive impacts on HP treatment toward acute paraquat poisoning, with better outcomes observed with Xuebijing, which should be considered for more frequent use in clinical practice.
机译：目的：由于血必净联合治疗对急性百草枯（PQ）中毒的作用尚不清楚。回顾性分析天津市第一中心医院119例百草枯中毒病例。根据治疗将患者分为3组。对照组（A组）采用常规治疗进行标准血液灌流，而实验组与血必净（B组）或乌司他丁（C组）联合进行血液灌流。短期（<7天）和长期（7-28天）的标准生物医学指标（例如器官功能障碍和死亡率）均已记录并汇总。然后，通过直接比较评估了血必净联合标准治疗的效果。结果表明，使用血必净或乌司他丁作为标准HP的其他治疗方法可显着改善总体预后，如较低的器官功能障碍和死亡率所证明。此外，与乌司他丁（C组）联合HP相比，血必净（B组）改善更明显（所有P <0.05）。我们的研究结果表明，血必净和乌拉司他汀均对急性百草枯中毒的HP治疗产生积极影响，血必净的观察结果更好，在临床实践中应考虑更频繁地使用。

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