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Postmastectomy Radiation Therapy: Are We Ready to Individualize Radiation?

机译:乳房切除术后放射疗法:我们准备好个性化放射了吗?

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摘要

Contemporary recommendations for postmastectomy radiation have undergone a shift in thinking away from simple stage based recommendations (one size fits all) to a system that considers both tumor biology and host factors. While surgical staging has traditionally dictated indications for postmastectomy radiation therapy (PMRT), our current understanding of tumor biology, host, immunoprofiles, and tumor microenvironment may direct a more personalized approach to radiation. Understanding the interaction of these variables may permit individualization of adjuvant therapy aimed at appropriate escalation and deescalation, including recommendations for PMRT. This article summarizes the current data regarding tumor and host molecular biomarkers in vitro and in vivo that support the individualization of PMRT and discusses open questions that may alter the future of breast cancer treatment.
机译:对于乳房切除术后放疗的当代建议已经发生了思想上的转变,从单纯的基于阶段的建议(一种尺寸适合所有建议)转变为同时考虑肿瘤生物学和宿主因素的系统。传统上,手术分期通常指示乳房切除术后放疗(PMRT)的适应症,但我们目前对肿瘤生物学,宿主,免疫学特征和肿瘤微环境的了解可能会指导更个性化的放射治疗。了解这些变量之间的相互作用可以使针对辅助治疗的个体化针对适当的升级和降级,包括针对PMRT的建议。本文总结了有关支持PMRT个性化的体外和体内肿瘤和宿主分子生物标志物的最新数据,并讨论了可能改变乳腺癌治疗未来的开放性问题。

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