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首页> 美国卫生研究院文献>Insects >Analysis of Salivary Glands and Saliva from Aedes albopictus and Aedes aegypti Infected with Chikungunya Viruses
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Analysis of Salivary Glands and Saliva from Aedes albopictus and Aedes aegypti Infected with Chikungunya Viruses

机译：基孔肯雅病毒感染的白纹伊蚊和埃及伊蚊唾液和唾液的分析

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Chikungunya virus (CHIKV) is a medically important mosquito-borne virus transmitted to humans by infected Aedes (Stegomyia) species. In 2013–2014, Ae. aegypti transmitted CHIKV to humans in the Caribbean and in 2005–2006, Ae. albopictus transmitted CHIKV on La Réunion Island (Indian Ocean basin). CHIKV LR2006 OPY1 from the La Réunion epidemic was associated with a mutation (E1:A226V) in the viral E1 glycoprotein that enhanced CHIKV transmission by Ae. albopictus. CHIKV from the Caribbean outbreak did not have the E1:A226V mutation. Here, we analyzed the salivary glands and saliva of Ae. albopictus strains from New Jersey, Florida, Louisiana and La Réunion after infection with each virus to determine their transmission potential. We infected the Ae. albopictus strains with blood meals containing 3–7 × 107 PFU/mL of each virus and analyzed the mosquitoes nine days later to maximize infection of their salivary glands. All four Ae. albopictus strains were highly susceptible to LR2006 OPY1 and viruses and their CHIKV disseminated infection rates (DIR) were statistically similar (p = 0.3916). The transmission efficiency rate (TER) was significantly lower for virus compared to LR2006 OPY1 virus in all Ae. albopictus strains and Ae. aegypti (Poza Rica) (p = 0.012) suggesting a salivary gland exit barrier to virus not seen with LR2006 OPY1 infections. If introduced, LR2006 OPY1 virus poses an increased risk of transmission by both Aedes species in the western hemisphere.
机译：基孔肯雅病毒（CHIKV）是一种医学上重要的蚊媒病毒，是由受感染的伊蚊（Stegomyia）物种传播给人类的。在2013–2014年，AE。 aegypti将CHIKV传播给了加勒比地区的人类，并于2005–2006年将其传播给了Ae。 albopictus在印度洋盆地的留尼汪岛上传播了CHIKV。 LaRéunion流行的CHIKV LR2006 OPY1与病毒E1糖蛋白中的突变（E1：A226V）相关，该突变增强了Ae的CHIKV传播。白化病。来自加勒比海爆发的CHIKV没有E1：A226V突变。在这里，我们分析了Ae的唾液腺和唾液。感染了每种病毒后，来自新泽西州，佛罗里达州，路易斯安那州和留尼汪岛的albopictus菌株将确定其传播潜能。我们感染了Ae。血粉中含有3–7×10 7 PFU / mL每种病毒的白粉虱菌株，并在9天后对蚊子进行了分析，以最大程度地感染唾液腺。四个Ae。白纹病菌菌株对LR2006 OPY1高度敏感，其病毒及其CHIKV传播感染率（DIR）在统计学上相似（p = 0.3916）。在所有Ae中，与LR2006 OPY1病毒相比，该病毒的传播效率（TER）明显较低。 albopictus菌株和Ae。 aegypti（Poza Rica）（p = 0.012）提示唾液腺出口屏障对LR2006 OPY1感染未见的病毒。如果引入，则LR2006 OPY1病毒会增加西半球两种伊蚊的传播风险。

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