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首页> 美国卫生研究院文献>Materials >Cellular Response to Doping of High Porosity Foamed Alumina with Ca P Mg and Si
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Cellular Response to Doping of High Porosity Foamed Alumina with Ca P Mg and Si

机译：CaPMg和Si对高孔隙率泡沫氧化铝掺杂的细胞响应

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Foamed alumina was previously synthesised by direct foaming of sulphate salt blends varying ammonium mole fraction (AMF), foaming heating rate and sintering temperature. The optimal product was produced with 0.33AMF, foaming at 100 °C/h and sintering at 1600 °C. This product attained high porosity of 94.39%, large average pore size of 300 µm and the highest compressive strength of 384 kPa. To improve bioactivity, doping of porous alumina by soaking in dilute or saturated solutions of Ca, P, Mg, CaP or CaP + Mg was done. Saturated solutions of Ca, P, Mg, CaP and CaP + Mg were made with excess salt in distilled water and decanted. Dilute solutions were made by diluting the 100% solution to 10% concentration. Doping with Si was done using the sol gel method at 100% concentration only. Cell culture was carried out with MG63 osteosarcoma cells. Cellular response to the Si and P doped samples was positive with high cell populations and cell layer formation. The impact of doping with phosphate produced a result not previously reported. The cellular response showed that both Si and P doping improved the biocompatibility of the foamed alumina.
机译：泡沫氧化铝以前是通过直接改变铵摩尔分数（AMF），发泡加热速率和烧结温度的硫酸盐混合物直接发泡而合成的。最佳产品的生产温度为0.33AMF，以100°C / h的速度发泡，并以1600°C的温度烧结。该产品的孔隙率高达94.39％，平均孔径大至300 µm，最高抗压强度为384 kPa。为了提高生物活性，通过浸泡在Ca，P，Mg，CaP或CaP + Mg的稀溶液或饱和溶液中来掺杂多孔氧化铝。用过量的盐在蒸馏水中制成饱和的Ca，P，Mg，CaP和CaP + Mg溶液，然后倒出。通过将100％溶液稀释至10％浓度来制备稀溶液。使用溶胶凝胶法仅以100％的浓度掺杂Si。用MG63骨肉瘤细胞进行细胞培养。在高细胞群体和细胞层形成的情况下，对Si和P掺杂样品的细胞反应为阳性。掺杂磷酸盐的影响产生了以前没有报道的结果。细胞反应表明，Si和P掺杂均改善了泡沫氧化铝的生物相容性。

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