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首页> 美国卫生研究院文献>Immunology >Experimental bovine trypanosomiasis. Changes in serum immunoglobulins complement and complement components in infected animals.
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Experimental bovine trypanosomiasis. Changes in serum immunoglobulins complement and complement components in infected animals.

机译：实验性牛锥虫病。感染动物血清免疫球蛋白补体和补体成分的变化。

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摘要

In three calves experimentally infected with Trypanosoma congolense the amounts of IgG1 and IgG2 were little changed and similar to those of normal animals. IgM increased in amount early in the infection and the amount of the increase appeared related to the parasite burden. The amounts of IgA and IgE were both much decreased and this also appeared related to the numbers of parasites in the blood. There was a decrease in the amounts of total haemolytic complement and complement components C1, C1q and C3 in the infected calves. Furthermore the amounts of properdin fluctuated with the cyclical changes in numbers of T. congolense parasites in the individual calves. No significant change in the amount of C8 was observed. It is considered that activation of both the alternative and the classical complement pathways occurs in trypanosome infected animals but that neither pathway goes to its terminal stages.
机译：在三只实验性感染锥虫锥虫的小牛中，IgG1和IgG2的量变化不大，与正常动物相似。在感染初期，IgM的量增加，并且增加的量似乎与寄生虫负担有关。 IgA和IgE的含量均大大降低，这也与血液中的寄生虫数量有关。受感染的小牛的总溶血补体和补体成分C1，C1q和C3的量减少了。此外，备受抑制的牛din素的量随个体小牛的锥虫T. congolense寄生虫数量的周期性变化而波动。没有观察到C8量的显着变化。据认为，替代性途径和经典补体途径的激活均在锥虫感染的动物中发生，但是这两种途径均未进入其终末期。

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